TY - GEN
T1 - Lipid fatty acid chain length influence over liposome physicochemical characteristics produced in a periodic disturbance mixer
AU - Lopez, Ruben R.
AU - Font De Rubinat, Paula G.
AU - Sanchez, Luz Maria
AU - Alazzam, Anas
AU - Stiharu, Ion
AU - Nerguizian, Vahe
N1 - Funding Information:
This work was supported by CONACyT-ETS (389081), Concordia University, NSERC (REN253), Khalifa University (CIRA-2019-014), and TS. We would like to acknowledge CMC Microsystems, NanoQAM as well as the Biology and Chemical department at UQAM, especially to G. Shul, K. Bergeron, and C. Mounier.
Funding Information:
ACKNOWLEDGMENT This work was supported by CONACyT-ETS (389081), Concordia University, NSERC (REN253), Khalifa University (CIRA-2019-014), and ÉTS.
Funding Information:
* This work was supported by the grant CONACyT (389081), CONACyT, Concordia University, NSREC (REN 253), Khalifa University (CIRA-2019-014) and ÉTS.
Publisher Copyright:
© 2020 IEEE.
PY - 2020/7
Y1 - 2020/7
N2 - Liposomes nanoparticles (LNPs) are versatile delivery systems that transport from drugs to genes. Liposome physicochemical properties determine how lipid nanoparticles will interact with biological systems. Thus, tuning these characteristics is of paramount importance for developing innovative formulations. Micromixers have shown to control average liposome size in a range relevant for drug delivery applications (50-200 nm) by changing the flow conditions. However, other factors might dramatically change liposome properties, such as the lipid fatty acid chain length. In this work, liposomes were produced using a periodic disturbance mixer (PDM) utilizing two different types of lipid mixtures, which differ solely in the number of carbons in the lipid fatty acid chain of the primary lipid as well as in the lipid mixture concentration. A clear relationship between these properties and liposome size and size distribution was found. The studied factors did not influence zeta potential results. The bending elasticity modulus of the studied lipids and their terminal head groups might play a role in the observed liposome properties.
AB - Liposomes nanoparticles (LNPs) are versatile delivery systems that transport from drugs to genes. Liposome physicochemical properties determine how lipid nanoparticles will interact with biological systems. Thus, tuning these characteristics is of paramount importance for developing innovative formulations. Micromixers have shown to control average liposome size in a range relevant for drug delivery applications (50-200 nm) by changing the flow conditions. However, other factors might dramatically change liposome properties, such as the lipid fatty acid chain length. In this work, liposomes were produced using a periodic disturbance mixer (PDM) utilizing two different types of lipid mixtures, which differ solely in the number of carbons in the lipid fatty acid chain of the primary lipid as well as in the lipid mixture concentration. A clear relationship between these properties and liposome size and size distribution was found. The studied factors did not influence zeta potential results. The bending elasticity modulus of the studied lipids and their terminal head groups might play a role in the observed liposome properties.
UR - http://www.scopus.com/inward/record.url?scp=85090999736&partnerID=8YFLogxK
U2 - 10.1109/NANO47656.2020.9183507
DO - 10.1109/NANO47656.2020.9183507
M3 - Conference contribution
AN - SCOPUS:85090999736
T3 - Proceedings of the IEEE Conference on Nanotechnology
SP - 324
EP - 328
BT - NANO 2020 - 20th IEEE International Conference on Nanotechnology, Proceedings
PB - IEEE Computer Society
T2 - 20th IEEE International Conference on Nanotechnology, NANO 2020
Y2 - 29 July 2020 through 31 July 2020
ER -