Ion-Based Metal/Graphene Antibacterial Agents Comprising Mono-Ionic and Bi-Ionic Silver and Copper Species

Anna Perdikaki, Angeliki Galeou, George Pilatos, Anastasia Prombona, Georgios N. Karanikolos

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Design of novel and more efficient antibacterial agents is a continuous and dynamic process due to the appearance of new pathogenic strains and inherent resistance development to existing antimicrobial treatments. Metallic nanoparticles (NPs) are highly investigated, yet the role of released ions is crucial in the antibacterial activity of the NP-based systems. We developed herein ion-based, metal/graphene hybrid structures comprising surface-bound Ag and Cu mono-ionic and Ag/Cu bi-ionic species on functionalized graphene, without involvement of NPs. The antibacterial performance of the resulting systems was evaluated against Escherichia coli cells using a series of parametrization experiments of varying metal ion types and concentrations and compared with that of the respective NP-based systems. It was found that the bi-ionic Ag/Cu-graphene materials exhibited superior performance compared to that of the mono-ionic analogues owing to the synergistic action of the combination of the two different metal ions on the surface and the enhancing role of the graphene support, whereas all ion-based systems performed superiorly compared to their NP-based counterparts of the same metal type and concentration. In addition, the materials exhibited sustained action, as their activity was maintained after reuse in repeated cycles employing fresh bacteria in each cycle. The systems developed herein may open new prospects toward the development of novel, efficient, and tunable antibacterial agents by properly supporting and configuring metals in ionic form.

Original languageBritish English
Pages (from-to)11156-11166
Number of pages11
JournalLangmuir
Volume34
Issue number37
DOIs
StatePublished - 18 Sep 2018

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