TY - GEN
T1 - Investigating Sleep Fragmentation by Autonomic Arousals in Depressed Patients with Obstructive Sleep Apnea
AU - Khandoker, Ahsan H.
AU - Alsaadi, Taoufik
AU - Kassie, Seada
AU - Hadjileontiadis, Leontios
N1 - Funding Information:
This study was supported by Al Jalila Foundation grant awarded to Drs L. Hadjileontiadis and A.H. Khandoker. Fatima BaFakih, Noura Sayed, Fatima Alshamshi, Reem Alneyadi and Fatima Khulood Alameri created Fig 1 of theamnuscript foretirhaCpstonerpoject.
Publisher Copyright:
© 2018 Creative Commons Attribution.
PY - 2018/9
Y1 - 2018/9
N2 - The aim of this study is to look at if there is any difference of arousal patterns in polysomnography (PSG) and Pulse Transit Time (PTT) recordings in Obstructive Sleep Apnea (OSA) patients with Major Depressive Disorder (MDD) and without MDD subjects. Nine overnight PSG recordings (7∼ 8 hours) were acquired from OSA subjects (AHI: 15∼ 60; 36.68 ± 13.55 events/hour) with MDD diagnoses [OSAMDD](5 cases) and OSA subjects (AHI: 15∼ 60; 38.37 ± 19.61) without MDD [OSA](4 cases) from a local psychiatric clinic. Selection criteria include the age [39.5± 5 vs 41.4± 3.5 yrs; p > 0.05] and weight [120.2± 10 vs 118.6± 12 Kgs; p > 0.05] matched subjects. Diagnoses of MDD were made by the Mini-International Neuropsychiatric Interview with ICD-10 questionnaire. A PTT arousal (ArPTT) was defined as a decrease in PTT by at least 15 milliseconds of the baseline lasting at least 5 seconds. Expert scored EEG based cortical arousals (ArEEG) include respiratory, movement, periodic leg movement and spontaneous arousals. Mann-Whitney U test showed that ArPTT index (events per hour) of OSA+MDD was significantly (p < 0.05) higher than that of OSA groups [36.56± 5.6 vs 28.78± 4.6]. In contrast, ArEEG indices in both groups were not found significantly different [24.18± 6.7 vs 25.74± 8.3].
AB - The aim of this study is to look at if there is any difference of arousal patterns in polysomnography (PSG) and Pulse Transit Time (PTT) recordings in Obstructive Sleep Apnea (OSA) patients with Major Depressive Disorder (MDD) and without MDD subjects. Nine overnight PSG recordings (7∼ 8 hours) were acquired from OSA subjects (AHI: 15∼ 60; 36.68 ± 13.55 events/hour) with MDD diagnoses [OSAMDD](5 cases) and OSA subjects (AHI: 15∼ 60; 38.37 ± 19.61) without MDD [OSA](4 cases) from a local psychiatric clinic. Selection criteria include the age [39.5± 5 vs 41.4± 3.5 yrs; p > 0.05] and weight [120.2± 10 vs 118.6± 12 Kgs; p > 0.05] matched subjects. Diagnoses of MDD were made by the Mini-International Neuropsychiatric Interview with ICD-10 questionnaire. A PTT arousal (ArPTT) was defined as a decrease in PTT by at least 15 milliseconds of the baseline lasting at least 5 seconds. Expert scored EEG based cortical arousals (ArEEG) include respiratory, movement, periodic leg movement and spontaneous arousals. Mann-Whitney U test showed that ArPTT index (events per hour) of OSA+MDD was significantly (p < 0.05) higher than that of OSA groups [36.56± 5.6 vs 28.78± 4.6]. In contrast, ArEEG indices in both groups were not found significantly different [24.18± 6.7 vs 25.74± 8.3].
UR - http://www.scopus.com/inward/record.url?scp=85068783356&partnerID=8YFLogxK
U2 - 10.22489/CinC.2018.175
DO - 10.22489/CinC.2018.175
M3 - Conference contribution
AN - SCOPUS:85068783356
T3 - Computing in Cardiology
BT - Computing in Cardiology Conference, CinC 2018
PB - IEEE Computer Society
T2 - 45th Computing in Cardiology Conference, CinC 2018
Y2 - 23 September 2018 through 26 September 2018
ER -