Intraocular endometrium in the rabbit as a model for endometriosis

J. A. Rock; R. A. Prendergast; D. Bobbie; W. R. Green; T. H. Parmley; N. H. Dubin

doi:10.1016/s0015-0282(16)55646-5

Intraocular endometrium in the rabbit as a model for endometriosis

J. A. Rock, R. A. Prendergast, D. Bobbie, W. R. Green, T. H. Parmley, N. H. Dubin

College of Medicine and Health Sciences

Emory University School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The model described suggests that endometrium can be successfully transplanted to the rabbit eye and observed through a slit lamp for morphological changes such as vascularization. Sampling of aqueous humor in volumes adequate for biochemical measurements have been demonstrated. Autografts of rabbit endometrium survived for up to 181 days. Although xenografts of human endometrial and endometriotic tissue demonstrate some adherence and vascularization, there is indication of immune rejection by day 7. Other treatment regimens will be explored with the objective of prolonging the graft survival time. The model has potential for direct observation of changes in endometrial tissue in response to hormonal treatment or for the testing of drug action on the endometrium. Furthermore, endometriotic secretory products may be measured in the aqueous humor of the anterior chamber.

Original language	British English
Pages (from-to)	232-235
Number of pages	4
Journal	Fertility and Sterility
Volume	59
Issue number	1
DOIs	https://doi.org/10.1016/s0015-0282(16)55646-5
State	Published - 1993

Keywords

autograft
Endometriosis
intraocular transplantation
zenograft

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title = "Intraocular endometrium in the rabbit as a model for endometriosis",

abstract = "The model described suggests that endometrium can be successfully transplanted to the rabbit eye and observed through a slit lamp for morphological changes such as vascularization. Sampling of aqueous humor in volumes adequate for biochemical measurements have been demonstrated. Autografts of rabbit endometrium survived for up to 181 days. Although xenografts of human endometrial and endometriotic tissue demonstrate some adherence and vascularization, there is indication of immune rejection by day 7. Other treatment regimens will be explored with the objective of prolonging the graft survival time. The model has potential for direct observation of changes in endometrial tissue in response to hormonal treatment or for the testing of drug action on the endometrium. Furthermore, endometriotic secretory products may be measured in the aqueous humor of the anterior chamber.",

keywords = "autograft, Endometriosis, intraocular transplantation, zenograft",

author = "Rock, {J. A.} and Prendergast, {R. A.} and D. Bobbie and Green, {W. R.} and Parmley, {T. H.} and Dubin, {N. H.}",

note = "Funding Information: Received June 29, 1992; revised and accepted September 17, 1992. * Supported in part by a research grant by ICI Pharmaceuticals, Wilmington, Delaware. t Presented at the Third World Congress on Endometriosis, Brussels, Belgium, June 1 to 3, 1992. *D epartment of Obstetrics and Gynecology. § Reprint requests and present address: John A. Rock, M.D., Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, Georgia 30303. II Present address: Department of Obstetrics and Gynecology, The Union Memorial Hospital, Baltimore, Maryland. 1f Department of Ophthalmology. ** Present address: Department of Obstetrics and Gynecology, University of Arkansas, Little Rock, Arkansas.",

year = "1993",

doi = "10.1016/s0015-0282(16)55646-5",

language = "British English",

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pages = "232--235",

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T1 - Intraocular endometrium in the rabbit as a model for endometriosis

AU - Rock, J. A.

AU - Prendergast, R. A.

AU - Bobbie, D.

AU - Green, W. R.

AU - Parmley, T. H.

AU - Dubin, N. H.

N1 - Funding Information: Received June 29, 1992; revised and accepted September 17, 1992. * Supported in part by a research grant by ICI Pharmaceuticals, Wilmington, Delaware. t Presented at the Third World Congress on Endometriosis, Brussels, Belgium, June 1 to 3, 1992. *D epartment of Obstetrics and Gynecology. § Reprint requests and present address: John A. Rock, M.D., Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, Georgia 30303. II Present address: Department of Obstetrics and Gynecology, The Union Memorial Hospital, Baltimore, Maryland. 1f Department of Ophthalmology. ** Present address: Department of Obstetrics and Gynecology, University of Arkansas, Little Rock, Arkansas.

PY - 1993

Y1 - 1993

N2 - The model described suggests that endometrium can be successfully transplanted to the rabbit eye and observed through a slit lamp for morphological changes such as vascularization. Sampling of aqueous humor in volumes adequate for biochemical measurements have been demonstrated. Autografts of rabbit endometrium survived for up to 181 days. Although xenografts of human endometrial and endometriotic tissue demonstrate some adherence and vascularization, there is indication of immune rejection by day 7. Other treatment regimens will be explored with the objective of prolonging the graft survival time. The model has potential for direct observation of changes in endometrial tissue in response to hormonal treatment or for the testing of drug action on the endometrium. Furthermore, endometriotic secretory products may be measured in the aqueous humor of the anterior chamber.

AB - The model described suggests that endometrium can be successfully transplanted to the rabbit eye and observed through a slit lamp for morphological changes such as vascularization. Sampling of aqueous humor in volumes adequate for biochemical measurements have been demonstrated. Autografts of rabbit endometrium survived for up to 181 days. Although xenografts of human endometrial and endometriotic tissue demonstrate some adherence and vascularization, there is indication of immune rejection by day 7. Other treatment regimens will be explored with the objective of prolonging the graft survival time. The model has potential for direct observation of changes in endometrial tissue in response to hormonal treatment or for the testing of drug action on the endometrium. Furthermore, endometriotic secretory products may be measured in the aqueous humor of the anterior chamber.

KW - autograft

KW - Endometriosis

KW - intraocular transplantation

KW - zenograft

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Intraocular endometrium in the rabbit as a model for endometriosis

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Keywords

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