Intraocular endometrium in the rabbit as a model for endometriosis

J. A. Rock, R. A. Prendergast, D. Bobbie, W. R. Green, T. H. Parmley, N. H. Dubin

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The model described suggests that endometrium can be successfully transplanted to the rabbit eye and observed through a slit lamp for morphological changes such as vascularization. Sampling of aqueous humor in volumes adequate for biochemical measurements have been demonstrated. Autografts of rabbit endometrium survived for up to 181 days. Although xenografts of human endometrial and endometriotic tissue demonstrate some adherence and vascularization, there is indication of immune rejection by day 7. Other treatment regimens will be explored with the objective of prolonging the graft survival time. The model has potential for direct observation of changes in endometrial tissue in response to hormonal treatment or for the testing of drug action on the endometrium. Furthermore, endometriotic secretory products may be measured in the aqueous humor of the anterior chamber.

Original languageBritish English
Pages (from-to)232-235
Number of pages4
JournalFertility and Sterility
Issue number1
StatePublished - 1993


  • autograft
  • Endometriosis
  • intraocular transplantation
  • zenograft


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