Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis

Adlan M. Elhassan; Abdu Adem; Nikos Papadogiannakis; Isam Suliman; Adel Gad; J. Urban Lindgren

doi:10.1016/S0165-5728(01)00263-6

Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis

Adlan M. Elhassan, Abdu Adem, Nikos Papadogiannakis, Isam Suliman, Adel Gad, J. Urban Lindgren

College of Medicine and Health Sciences

Huddinge Hospital

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effects of somatostatin on the development of adjuvant arthritis induced by Mycobacterium butyricum were studied. Somatostatin was injected into the lateral cerebral ventricle every day for 14 days beginning on the first day of mycobacteria inoculation in the preventive group. In the treatment group, somatostatin was injected from day 17 until day 30 post-mycobacteria inoculation. Arthritis was evaluated by measuring ankle joint circumference and diameter as well as microscopic examination of ankle joint sections. Somatostatin profoundly inhibited the development of adjuvant arthritis and an anti-inflammatory action was observed in the treatment group. These results suggest that somatostatin has a central action that can prevent or attenuate symptoms associated with arthritis.

Original language	British English
Pages (from-to)	15-20
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	116
Issue number	1
DOIs	https://doi.org/10.1016/S0165-5728(01)00263-6
State	Published - 1 May 2001

Keywords

Adjuvant
Arthritis
Somatostatin
Synovium

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10.1016/S0165-5728(01)00263-6

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title = "Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis",

abstract = "The effects of somatostatin on the development of adjuvant arthritis induced by Mycobacterium butyricum were studied. Somatostatin was injected into the lateral cerebral ventricle every day for 14 days beginning on the first day of mycobacteria inoculation in the preventive group. In the treatment group, somatostatin was injected from day 17 until day 30 post-mycobacteria inoculation. Arthritis was evaluated by measuring ankle joint circumference and diameter as well as microscopic examination of ankle joint sections. Somatostatin profoundly inhibited the development of adjuvant arthritis and an anti-inflammatory action was observed in the treatment group. These results suggest that somatostatin has a central action that can prevent or attenuate symptoms associated with arthritis.",

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AU - Elhassan, Adlan M.

AU - Adem, Abdu

AU - Papadogiannakis, Nikos

AU - Suliman, Isam

AU - Gad, Adel

AU - Lindgren, J. Urban

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N2 - The effects of somatostatin on the development of adjuvant arthritis induced by Mycobacterium butyricum were studied. Somatostatin was injected into the lateral cerebral ventricle every day for 14 days beginning on the first day of mycobacteria inoculation in the preventive group. In the treatment group, somatostatin was injected from day 17 until day 30 post-mycobacteria inoculation. Arthritis was evaluated by measuring ankle joint circumference and diameter as well as microscopic examination of ankle joint sections. Somatostatin profoundly inhibited the development of adjuvant arthritis and an anti-inflammatory action was observed in the treatment group. These results suggest that somatostatin has a central action that can prevent or attenuate symptoms associated with arthritis.

AB - The effects of somatostatin on the development of adjuvant arthritis induced by Mycobacterium butyricum were studied. Somatostatin was injected into the lateral cerebral ventricle every day for 14 days beginning on the first day of mycobacteria inoculation in the preventive group. In the treatment group, somatostatin was injected from day 17 until day 30 post-mycobacteria inoculation. Arthritis was evaluated by measuring ankle joint circumference and diameter as well as microscopic examination of ankle joint sections. Somatostatin profoundly inhibited the development of adjuvant arthritis and an anti-inflammatory action was observed in the treatment group. These results suggest that somatostatin has a central action that can prevent or attenuate symptoms associated with arthritis.

KW - Adjuvant

KW - Arthritis

KW - Somatostatin

KW - Synovium

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Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis

Abstract

Keywords

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