Interval bone mineral density with long-term gonadotropin-releasing hormone agonist suppression

M. D. Damewood, W. D. Schlaff, J. S. Hesla, J. A. Rock

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22 Scopus citations


Twenty-six patients of mean age 37 ± 4.8 (SD) years, who received a 6-month course of gonadotropin-releasing hormone (GnRH) analogue, were selected for study. Bone mineral density (BMD) was measured by dual-photon absorptiometry before initiation and after completion of agonist therapy. Mean BMD (g/cm2) by dual-photon absorptiometry at L2 to L4, femoral neck, Ward's triangle, and the trochanteric area did not change significantly (P = not significant [NS]) after 6 months of GnRH analogue suppression. Mean percent (%) expected density as standardized for age, weight, and sex remained in the range of 89.3% to 94.2% (P = NS). The interval detectable change in BMD after therapy was 0.05 ± 0.06 g/cm2. These findings are reassuring with respect to the use of long-term GnRH analogue regimens to induce a hypoestrogenic state in the treatment of hormone-dependent conditions.

Original languageBritish English
Pages (from-to)596-599
Number of pages4
JournalFertility and Sterility
Issue number4
StatePublished - 1989


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