Intergenomic consensus in multifactorial inheritance loci: The case of multiple sclerosis

P. Serrano-Fernández, S. M. Ibrahim, U. K. Zettl, H. J. Thiesen, R. Gödde, J. T. Epplen, S. Möller

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Genetic linkage and association studies define chromosomal regions, quantitative trait loci (QTLs), which influence the phenotype of polygenic diseases. Here, we describe a global approach to determine intergenomic consensus of those regions in order to fine map QTLs and select particularly promising candidate genes for disease susceptibility or other polygenic traits. Exemplarily, human multiple sclerosis (MS) susceptibility regions were compared for sequence similarity with mouse and rat QTLs in its animal model experimental allergic encephalomyelitis (EAE). The number of intergenomic MS/EAE consensus genes (295) is significantly higher than expected if the animal model was unrelated to the human disease. Hence, this approach contributes to the empirical evaluation of animal models for their applicability to the study of human diseases.

Original languageBritish English
Pages (from-to)615-620
Number of pages6
JournalGenes and Immunity
Volume5
Issue number8
DOIs
StatePublished - Dec 2004

Keywords

  • Comparative genomics
  • Experimental allergic encephalomyelitis (EAE)
  • Intergenomics
  • Multiple sclerosis (MS)
  • Quantitative trait locus (QTL)

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