Interaction of homocysteine, glutathione and 8-hydroxy-2′-deoxyguanosine in metabolic syndrome progression

E. G. Butkowski; H. A. Al-Aubaidy; H. F. Jelinek

doi:10.1016/j.clinbiochem.2016.10.006

Interaction of homocysteine, glutathione and 8-hydroxy-2′-deoxyguanosine in metabolic syndrome progression

E. G. Butkowski, H. A. Al-Aubaidy, H. F. Jelinek

Biomedical Engineering & Biotechnology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Purpose The role of homocysteine (Hcy) and associated oxidative stress processes in the metabolic syndrome (MetS) continuum has not been explored extensively. Changes in Hcy and associated oxidative stress in relation to the number of metabolic syndrome factors present are explored in this study. Method Participants (n = 266) attending a rural diabetes screening clinic had their medical history recorded as well as body mass index, Hcy, glucose, cholesterol, glutathione (GSH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) measured. Result A significant elevation in Hcy (9.5 μmol/L ± 2 vs. 10.6 μmol/L ± 3, p = 0.03) and 8-OHdG (307 pg/mL ± 516 vs. 1130 pg/mL ± 1155, p = 0.0001) was observed between the noMetS and MetS groups. Hcy increased with the addition of MetS factors paralleled by 8-OHdG and GSH. A dramatic increase was seen in 8-OHdG, nearly doubling between 2 MetS and 3 MetS factors present (p = 0.0001). Conclusion Homocysteine may be a useful marker together with 8-OHdG in assessing the extent of metabolic syndrome in a rural population.

Original language	British English
Pages (from-to)	116-120
Number of pages	5
Journal	Clinical Biochemistry
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.clinbiochem.2016.10.006
State	Published - 1 Feb 2017

Keywords

8-OHdG
Glutathione
Homocysteine
Metabolic syndrome
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinbiochem.2016.10.006

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title = "Interaction of homocysteine, glutathione and 8-hydroxy-2′-deoxyguanosine in metabolic syndrome progression",

abstract = "Purpose The role of homocysteine (Hcy) and associated oxidative stress processes in the metabolic syndrome (MetS) continuum has not been explored extensively. Changes in Hcy and associated oxidative stress in relation to the number of metabolic syndrome factors present are explored in this study. Method Participants (n = 266) attending a rural diabetes screening clinic had their medical history recorded as well as body mass index, Hcy, glucose, cholesterol, glutathione (GSH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) measured. Result A significant elevation in Hcy (9.5 μmol/L ± 2 vs. 10.6 μmol/L ± 3, p = 0.03) and 8-OHdG (307 pg/mL ± 516 vs. 1130 pg/mL ± 1155, p = 0.0001) was observed between the noMetS and MetS groups. Hcy increased with the addition of MetS factors paralleled by 8-OHdG and GSH. A dramatic increase was seen in 8-OHdG, nearly doubling between 2 MetS and 3 MetS factors present (p = 0.0001). Conclusion Homocysteine may be a useful marker together with 8-OHdG in assessing the extent of metabolic syndrome in a rural population.",

keywords = "8-OHdG, Glutathione, Homocysteine, Metabolic syndrome, Oxidative stress",

author = "Butkowski, {E. G.} and Al-Aubaidy, {H. A.} and Jelinek, {H. F.}",

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AU - Al-Aubaidy, H. A.

AU - Jelinek, H. F.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Purpose The role of homocysteine (Hcy) and associated oxidative stress processes in the metabolic syndrome (MetS) continuum has not been explored extensively. Changes in Hcy and associated oxidative stress in relation to the number of metabolic syndrome factors present are explored in this study. Method Participants (n = 266) attending a rural diabetes screening clinic had their medical history recorded as well as body mass index, Hcy, glucose, cholesterol, glutathione (GSH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) measured. Result A significant elevation in Hcy (9.5 μmol/L ± 2 vs. 10.6 μmol/L ± 3, p = 0.03) and 8-OHdG (307 pg/mL ± 516 vs. 1130 pg/mL ± 1155, p = 0.0001) was observed between the noMetS and MetS groups. Hcy increased with the addition of MetS factors paralleled by 8-OHdG and GSH. A dramatic increase was seen in 8-OHdG, nearly doubling between 2 MetS and 3 MetS factors present (p = 0.0001). Conclusion Homocysteine may be a useful marker together with 8-OHdG in assessing the extent of metabolic syndrome in a rural population.

AB - Purpose The role of homocysteine (Hcy) and associated oxidative stress processes in the metabolic syndrome (MetS) continuum has not been explored extensively. Changes in Hcy and associated oxidative stress in relation to the number of metabolic syndrome factors present are explored in this study. Method Participants (n = 266) attending a rural diabetes screening clinic had their medical history recorded as well as body mass index, Hcy, glucose, cholesterol, glutathione (GSH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) measured. Result A significant elevation in Hcy (9.5 μmol/L ± 2 vs. 10.6 μmol/L ± 3, p = 0.03) and 8-OHdG (307 pg/mL ± 516 vs. 1130 pg/mL ± 1155, p = 0.0001) was observed between the noMetS and MetS groups. Hcy increased with the addition of MetS factors paralleled by 8-OHdG and GSH. A dramatic increase was seen in 8-OHdG, nearly doubling between 2 MetS and 3 MetS factors present (p = 0.0001). Conclusion Homocysteine may be a useful marker together with 8-OHdG in assessing the extent of metabolic syndrome in a rural population.

KW - 8-OHdG

KW - Glutathione

KW - Homocysteine

KW - Metabolic syndrome

KW - Oxidative stress

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Interaction of homocysteine, glutathione and 8-hydroxy-2′-deoxyguanosine in metabolic syndrome progression

Abstract

Keywords

UN SDGs

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