TY - JOUR
T1 - Intelligent In situ Printing of Multimaterial Bioinks for First-Aid Wound Care Guided by Eye-In-Hand Robot Technology
AU - Jeong, Seol Ha
AU - Kim, Jihyun
AU - Thibault, Brendan Craig
AU - Soto, Javier Alejandro Lozano
AU - Tourk, Fatima
AU - Steakelum, Joshua
AU - Azuela, Diego
AU - Carvalho, Violeta
AU - Quiroga-Ocaña, Guillermo
AU - Zhuang, Weida
AU - Cham-Pérez, Mei Li L.
AU - Huang, Lucia L.
AU - Li, Zhuqing
AU - Valsami, Eleftheria Angeliki
AU - Wang, Enya
AU - Rodrigues, Nelson
AU - Teixeira, Senhorinha F.C.F.
AU - Lee, Yuhan
AU - Seo, Jungmok
AU - Veves, Aristidis
AU - Hassan, Shabir
AU - Theocharidis, Georgios
AU - Fiondella, Lance
AU - Shin, Su Ryon
N1 - Publisher Copyright:
© 2024 Wiley-VCH GmbH.
PY - 2024/6/5
Y1 - 2024/6/5
N2 - INSIGHT (INtelligent in situ printing Guided by Eye-in-Hand robot Technology), an innovative computer vision-enabled system that combines a depth camera with a 6-degree of freedom robot arm, empowering it to identify arbitrary areas at various angles through real time adjustments and to enable volumetric printing performed by dynamic image recognition based on color and contour differences is presented. Continuous targeting of multiple wounds at different locations is achieved. The optimized pneumatic valve synchronized with the INSIGHT can print multiple inks with diverse rheological properties to fabricate scaffolds and bandages with the capacity to treat various types of wounds. The design of dual printed modes, such as extrusion and spray, can significantly decrease printing time for large-scale wounds on an ex vivo porcine model. INSIGHT demonstrates its ability to treat diabetic wounds, using a microgel-based ink possessing an inherent porous microstructure to facilitate cell infiltration. In vivo verification highlights its adaptability to enable customized care for rapid emergency treatment of trauma patients.
AB - INSIGHT (INtelligent in situ printing Guided by Eye-in-Hand robot Technology), an innovative computer vision-enabled system that combines a depth camera with a 6-degree of freedom robot arm, empowering it to identify arbitrary areas at various angles through real time adjustments and to enable volumetric printing performed by dynamic image recognition based on color and contour differences is presented. Continuous targeting of multiple wounds at different locations is achieved. The optimized pneumatic valve synchronized with the INSIGHT can print multiple inks with diverse rheological properties to fabricate scaffolds and bandages with the capacity to treat various types of wounds. The design of dual printed modes, such as extrusion and spray, can significantly decrease printing time for large-scale wounds on an ex vivo porcine model. INSIGHT demonstrates its ability to treat diabetic wounds, using a microgel-based ink possessing an inherent porous microstructure to facilitate cell infiltration. In vivo verification highlights its adaptability to enable customized care for rapid emergency treatment of trauma patients.
KW - in situ bioprinting
KW - robot printing
KW - spray printing
KW - visual guidance
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85186605696&partnerID=8YFLogxK
U2 - 10.1002/admt.202400060
DO - 10.1002/admt.202400060
M3 - Article
AN - SCOPUS:85186605696
SN - 2365-709X
VL - 9
JO - Advanced Materials Technologies
JF - Advanced Materials Technologies
IS - 11
M1 - 2400060
ER -