@article{2cb0b8da009147bda1f9d822a572968d,
title = "Infrequent transmission of monovalent human rotavirus vaccine virus to household contacts of vaccinated infants in Malawi",
abstract = "Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8-10 days after vaccine). RV1 vaccine virus in stool was detected using semi-quantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68\%) and in 2 of 147 household contacts (1.4\%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.",
keywords = "Indirect effects, Malawi, Rotavirus, Transmission, Vaccine",
author = "Aisleen Bennett and Louisa Pollock and Jere, \{Khuzwayo C.\} and Pitzer, \{Virginia E.\} and Benjamin Lopman and Umesh Parashar and Dean Everett and Heyderman, \{Robert S.\} and Naor Bar-Zeev and Cunliffe, \{Nigel A.\} and Miren Iturriza-Gomara",
note = "Funding Information: Potential conflicts of interest. K. C. J. and N. B. Z. have received research grant support from GlaxoSmithKline Biologicals for work on rotavirus vaccines. N. A. C. has received research grant support and honoraria for participation in rotavirus vaccine advisory board meetings from GlaxoSmithKline Biologicals. M. I. G. has received research grant support from GlaxoSmithKline Biologicals and Sanofi Pasteur MSD for work on rotavirus. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Funding Information: Financial support. This study was supported by Wellcome Trust (clinical PhD fellowship grants 102466/Z/13/A to A. B. and 102464/Z/13/A to L. P., program grant 091909/Z/10/Z, and training fellowship grant 201945/Z/16/Z to K. C. J.), the Malawi-Liverpool-Wellcome Trust Clinical Research Programme (Wellcome Trust core grant strategic award 101113/Z/13/Z), and the US National Institutes of Health (grant R01-AI112970 to V. E. P.). The authors received no financial support or other form of compensation related to the development of the manuscript. Funding Information: This study was supported by Wellcome Trust (clinical PhD fellowship grants 102466/Z/13/A to A. B. and 102464/Z/13/A to L. P., program grant 091909/Z/10/Z, and training fellowship grant 201945/Z/16/Z to K. C. J.), the Malawi-Liverpool-Wellcome Trust Clinical Research Programme (Wellcome Trust core grant strategic award 101113/Z/13/Z), and the US National Institutes of Health (grant R01-AI112970 to V. E. P.). The authors received no financial support or other form of compensation related to the development of the manuscript. Publisher Copyright: {\textcopyright} The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2019",
month = jun,
day = "1",
doi = "10.1093/infdis/jiz002",
language = "British English",
volume = "219",
pages = "1730--1734",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "11",
}
