Incremental Cross-Domain Adaptation for Robust Retinopathy Screening via Bayesian Deep Learning

Taimur Hassan, Bilal Hassan, Muhammad Usman Akram, Shahrukh Hashmi, Abdel Hakim Taguri, Naoufel Werghi

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Retinopathy represents a group of retinal diseases that, if not treated timely, can cause severe visual impairments or even blindness. Many researchers have developed autonomous systems to recognize retinopathy via fundus and optical coherence tomography (OCT) imagery. However, most of these frameworks employ conventional transfer learning and fine-tuning approaches, requiring a decent amount of well-annotated training data to produce accurate diagnostic performance. This article presents a novel incremental cross-domain adaptation instrument that allows any deep classification model to progressively learn abnormal retinal pathologies in OCT and fundus imagery via few-shot training. Furthermore, unlike its competitors, the proposed instrument is driven via a Bayesian multiobjective function that not only enforces the candidate classification network to retain its prior learned knowledge during incremental training, but also ensures that the network understands the structural and semantic relationships between previously learned pathologies and newly added disease categories to effectively recognize them at the inference stage. The proposed framework, evaluated on six public datasets acquired with three different scanners to screen 13 retinal pathologies, outperforms the state-of-the-art competitors by achieving an overall accuracy and F1 score of 0.9826 and 0.9846, respectively.

Original languageBritish English
JournalIEEE Transactions on Instrumentation and Measurement
StatePublished - 2021


  • Bayesian deep learning
  • fundus photography
  • incremental domain adaptation (DA)
  • optical coherence tomography
  • retinopathy


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