Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice

Dietrich E. Lorke, Chi Wang Ip, Udo Schumacher

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

To assess the in vivo influence of the systemic immune system upon microglia, six defined brain regions of adult SCID mice (n = 10) lacking functional T- and B-lymphocytes have been analyzed by NDPase histochemistry, morphometry and immunohistochemistry. Despite absence of neuropathology and lack of microglial activation, microglial numerical density was significantly increased in SCID mice. Elevation was most marked in the cerebellar granular layer (by 32.6%; 95% confidence interval: 9.9-58.7%), followed by the fimbria hippocampi and the molecular layer of hippocampal CA1/CA3 region. These data need to be taken into account when using SCID mice as a model for microglial reaction in immunodeficient mice.

Original languageBritish English
Pages (from-to)693-697
Number of pages5
JournalHistochemistry and Cell Biology
Volume130
Issue number4
DOIs
StatePublished - Oct 2008

Keywords

  • Cerebellum
  • Lymphocytes
  • Macrophages
  • Microglia
  • SCID mice

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