In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Ayesha Ashraf; Rehana Sharif; Munir Ahmad; Misbah Masood; Abubakar Shahid; Dalaver H. Anjum; Muhammad Shahid Rafique; Sheeba Ghani

doi:10.1049/iet-nbt.2014.0075

In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Ayesha Ashraf
, Rehana Sharif
, Munir Ahmad
, Misbah Masood
, Abubakar Shahid
, Dalaver H. Anjum
, Muhammad Shahid Rafique
, Sheeba Ghani

Physics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that ^99mTc-AgNPs and ^99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but ^99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.

Original language	British English
Pages (from-to)	368-374
Number of pages	7
Journal	IET Nanobiotechnology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1049/iet-nbt.2014.0075
State	Published - 1 Dec 2015

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title = "In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit",

abstract = "Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88\%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.",

author = "Ayesha Ashraf and Rehana Sharif and Munir Ahmad and Misbah Masood and Abubakar Shahid and Anjum, \{Dalaver H.\} and Rafique, \{Muhammad Shahid\} and Sheeba Ghani",

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doi = "10.1049/iet-nbt.2014.0075",

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T1 - In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

AU - Ashraf, Ayesha

AU - Sharif, Rehana

AU - Ahmad, Munir

AU - Masood, Misbah

AU - Shahid, Abubakar

AU - Anjum, Dalaver H.

AU - Rafique, Muhammad Shahid

AU - Ghani, Sheeba

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.

AB - Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.

UR - https://www.scopus.com/pages/publications/84949566447

U2 - 10.1049/iet-nbt.2014.0075

DO - 10.1049/iet-nbt.2014.0075

M3 - Article

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AN - SCOPUS:84949566447

SN - 1751-8741

VL - 9

SP - 368

EP - 374

JO - IET Nanobiotechnology

JF - IET Nanobiotechnology

IS - 6

ER -

In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Abstract

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