In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Ayesha Ashraf; Rehana Sharif; Munir Ahmad; Misbah Masood; Abubakar Shahid; Dalaver H. Anjum; Muhammad Shahid Rafique; Sheeba Ghani

doi:10.1049/iet-nbt.2014.0075

In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Ayesha Ashraf, Rehana Sharif, Munir Ahmad, Misbah Masood, Abubakar Shahid, Dalaver H. Anjum, Muhammad Shahid Rafique, Sheeba Ghani

Physics

Research output: Contribution to journal › Article › peer-review

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Abstract

Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that ^99mTc-AgNPs and ^99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but ^99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.

Original language	British English
Pages (from-to)	368-374
Number of pages	7
Journal	IET Nanobiotechnology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1049/iet-nbt.2014.0075
State	Published - 1 Dec 2015

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title = "In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit",

abstract = "Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.",

author = "Ayesha Ashraf and Rehana Sharif and Munir Ahmad and Misbah Masood and Abubakar Shahid and Anjum, {Dalaver H.} and Rafique, {Muhammad Shahid} and Sheeba Ghani",

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T1 - In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

AU - Ashraf, Ayesha

AU - Sharif, Rehana

AU - Ahmad, Munir

AU - Masood, Misbah

AU - Shahid, Abubakar

AU - Anjum, Dalaver H.

AU - Rafique, Muhammad Shahid

AU - Ghani, Sheeba

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.

AB - Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.

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SN - 1751-8741

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EP - 374

JO - IET Nanobiotechnology

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ER -

In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Abstract

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