In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO2/Curcumin for wound healing application

J. Prakash; K. S. Venkataprasanna; G. Bharath; Fawzi Banat; R. Niranjan; G. Devanand Venkatasubbu

doi:10.1016/j.colsurfa.2021.127166

In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO₂/Curcumin for wound healing application

J. Prakash
, K. S. Venkataprasanna
, G. Bharath
, Fawzi Banat
, R. Niranjan
, G. Devanand Venkatasubbu

Chemical and Petroleum Engineering

SRM University

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO₂/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electrospinning was used to fabricate the CA/GO/TiO₂/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO₂/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO₂/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO₂/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitro analysis confirmed that CA/GO/TiO₂/curcumin nanofiber has the potential to be used as a wound dressing material.

Original language	British English
Article number	127166
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	627
DOIs	https://doi.org/10.1016/j.colsurfa.2021.127166
State	Published - 20 Oct 2021

Keywords

Cell proliferation
Cellulose acetate (CA) nanofiber
Curcumin
Hemocompatible
Wound dressing materials

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Prakash, J., Venkataprasanna, K. S., Bharath, G., Banat, F., Niranjan, R., & Venkatasubbu, G. D. (2021). In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO₂/Curcumin for wound healing application. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 627, Article 127166. https://doi.org/10.1016/j.colsurfa.2021.127166

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title = "In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO2/Curcumin for wound healing application",

abstract = "Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electrospinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitro analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.",

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AU - Banat, Fawzi

AU - Niranjan, R.

AU - Venkatasubbu, G. Devanand

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N2 - Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electrospinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitro analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.

AB - Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electrospinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitro analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.

KW - Cell proliferation

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