TY - JOUR
T1 - In-vitro evaluation of electrospun cellulose acetate nanofiber containing Graphene oxide/TiO2/Curcumin for wound healing application
AU - Prakash, J.
AU - Venkataprasanna, K. S.
AU - Bharath, G.
AU - Banat, Fawzi
AU - Niranjan, R.
AU - Venkatasubbu, G. Devanand
N1 - Funding Information:
The authors J. Prakash and G. Devanand Venkatasubbu thank the department of physics and nanotechnology, SRM Institute of Science and Technology, for providing the lab facilities.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/10/20
Y1 - 2021/10/20
N2 - Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electrospinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitro analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.
AB - Graphene-based dressings have gained interest in wound healing due to their biocompatibility and antimicrobial properties. This study developed a graphene oxide/TiO2/curcumin integrated cellulose acetate (CA) nanofiber for wound dressing applications. Electrospinning was used to fabricate the CA/GO/TiO2/curcumin nanofiber. The formation of CA nanofiber was clearly visible using FE-SEM. The presence of curcumin in CA/GO/TiO2/curcumin nanofiber was confirmed by FT-IR analysis. The prepared nanofiber was characterized by swelling, degradation, tensile strength, and in-vitro wound healing properties. CA/GO/TiO2/curcumin nanofiber demonstrated considerable antibacterial activity against wound pathogens and improved wound healing, as confirmed by MTT and migration assays. The fabricated CA/GO/TiO2/curcumin nanofiber exhibited exceptional hemocompatibility and biocompatibility. The drug release study revealed that sustained curcumin release would improve skin regeneration and wound healing. Invitro analysis confirmed that CA/GO/TiO2/curcumin nanofiber has the potential to be used as a wound dressing material.
KW - Cell proliferation
KW - Cellulose acetate (CA) nanofiber
KW - Curcumin
KW - Hemocompatible
KW - Wound dressing materials
UR - http://www.scopus.com/inward/record.url?scp=85109806236&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfa.2021.127166
DO - 10.1016/j.colsurfa.2021.127166
M3 - Article
AN - SCOPUS:85109806236
SN - 0927-7757
VL - 627
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
M1 - 127166
ER -