Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

Zahra Rezaei; Dilara Yilmaz-Aykut; Fatima Mumtaza Tourk; Nicole Bassous; Margot Barroso-Zuppa; Asif Iqbal Shawl; Syed Salman Ashraf; Huseyin Avci; Shabir Hassan

doi:10.3390/pharmaceutics14102244

Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

Zahra Rezaei
, Dilara Yilmaz-Aykut
, Fatima Mumtaza Tourk
, Nicole Bassous
, Margot Barroso-Zuppa
, Asif Iqbal Shawl
, Syed Salman Ashraf
, Huseyin Avci
, Shabir Hassan

Harvard Medical School
Sharif University of Technology
Istanbul University-Cerrahpaşa
Northeastern University
Tecnologico de Monterrey
Eskisehir Osmangazi University

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.

Original language	British English
Article number	2244
Journal	Pharmaceutics
Volume	14
Issue number	10
DOIs	https://doi.org/10.3390/pharmaceutics14102244
State	Published - Oct 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biomaterials
foreign body response
hydrogels
immune modulation
tissue engineering

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10.3390/pharmaceutics14102244

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title = "Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications",

abstract = "Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.",

keywords = "biomaterials, foreign body response, hydrogels, immune modulation, tissue engineering",

author = "Zahra Rezaei and Dilara Yilmaz-Aykut and Tourk, \{Fatima Mumtaza\} and Nicole Bassous and Margot Barroso-Zuppa and Shawl, \{Asif Iqbal\} and Ashraf, \{Syed Salman\} and Huseyin Avci and Shabir Hassan",

note = "Funding Information: This study was supported by Khalifa University{\textquoteright}s FSU 8474000442/FSU-2022-022 to Shabir Hassan. Publisher Copyright: {\textcopyright} 2022 by the authors.",

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month = oct,

doi = "10.3390/pharmaceutics14102244",

language = "British English",

volume = "14",

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AU - Rezaei, Zahra

AU - Yilmaz-Aykut, Dilara

AU - Tourk, Fatima Mumtaza

AU - Bassous, Nicole

AU - Barroso-Zuppa, Margot

AU - Shawl, Asif Iqbal

AU - Ashraf, Syed Salman

AU - Avci, Huseyin

AU - Hassan, Shabir

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N2 - Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.

AB - Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.

KW - biomaterials

KW - foreign body response

KW - hydrogels

KW - immune modulation

KW - tissue engineering

UR - https://www.scopus.com/pages/publications/85140823230

U2 - 10.3390/pharmaceutics14102244

DO - 10.3390/pharmaceutics14102244

M3 - Review article

AN - SCOPUS:85140823230

SN - 1999-4923

VL - 14

JO - Pharmaceutics

JF - Pharmaceutics

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M1 - 2244

ER -

Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

Abstract

UN SDGs

Keywords

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