Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Farheen Badrealam Khan; Shahab Uddin; Abozer Y. Elderdery; Khang Wen Goh; Long Chiau Ming; Chrismawan Ardianto; Abdul Rasheed Palakot; Irfa Anwar; Mohsina Khan; Mohammad Owais; Chih Yang Huang; Jayasimha Rayalu Daddam; Meraj Alam Khan; Shoaib Shoaib; Md Khursheed; Sara Reshadat; Hamid Reza Khayat Kashani; Sameer Mirza; Abbas A. Khaleel; Mohammed Akli Ayoub

doi:10.3390/cells11223664

Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Farheen Badrealam Khan
, Shahab Uddin
, Abozer Y. Elderdery
, Khang Wen Goh
, Long Chiau Ming
, Chrismawan Ardianto
, Abdul Rasheed Palakot
, Irfa Anwar
, Mohsina Khan
, Mohammad Owais
, Chih Yang Huang
, Jayasimha Rayalu Daddam
, Meraj Alam Khan
, Shoaib Shoaib
, Md Khursheed
, Sara Reshadat
, Hamid Reza Khayat Kashani
, Sameer Mirza
, Abbas A. Khaleel
, Mohammed Akli Ayoub

Biological Sciences

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

Original language	British English
Article number	3664
Journal	Cells
Volume	11
Issue number	22
DOIs	https://doi.org/10.3390/cells11223664
State	Published - Nov 2022

Keywords

cardiovascular disease
circRNA
exosomes
lncRNA
miRNA
ncRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells11223664

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Khan, F. B., Uddin, S., Elderdery, A. Y., Goh, K. W., Ming, L. C., Ardianto, C., Palakot, A. R., Anwar, I., Khan, M., Owais, M., Huang, C. Y., Daddam, J. R., Khan, M. A., Shoaib, S., Khursheed, M., Reshadat, S., Khayat Kashani, H. R., Mirza, S., Khaleel, A. A., & Ayoub, M. A. (2022). Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential. Cells, 11(22), Article 3664. https://doi.org/10.3390/cells11223664

@article{75ae12639c1047a7ac659a521ad7327c,

title = "Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential",

abstract = "Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.",

keywords = "cardiovascular disease, circRNA, exosomes, lncRNA, miRNA, ncRNA",

author = "Khan, \{Farheen Badrealam\} and Shahab Uddin and Elderdery, \{Abozer Y.\} and Goh, \{Khang Wen\} and Ming, \{Long Chiau\} and Chrismawan Ardianto and Palakot, \{Abdul Rasheed\} and Irfa Anwar and Mohsina Khan and Mohammad Owais and Huang, \{Chih Yang\} and Daddam, \{Jayasimha Rayalu\} and Khan, \{Meraj Alam\} and Shoaib Shoaib and Md Khursheed and Sara Reshadat and \{Khayat Kashani\}, \{Hamid Reza\} and Sameer Mirza and Khaleel, \{Abbas A.\} and Ayoub, \{Mohammed Akli\}",

note = "Funding Information: Zayed Center for Health Sciences, United Arab Emirates University (UAEU-ZCHS) (Grant number \#31R235) and the UAEU postdoc grant (Grant number \#31R241). Funding Information: We acknowledge the funding support by a center-based grant from Zayed Center for Health Sciences, United Arab Emirates University. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = nov,

doi = "10.3390/cells11223664",

language = "British English",

volume = "11",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "22",

}

Khan, FB, Uddin, S, Elderdery, AY, Goh, KW, Ming, LC, Ardianto, C, Palakot, AR, Anwar, I, Khan, M, Owais, M, Huang, CY, Daddam, JR, Khan, MA, Shoaib, S, Khursheed, M, Reshadat, S, Khayat Kashani, HR, Mirza, S, Khaleel, AA & Ayoub, MA 2022, 'Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential', Cells, vol. 11, no. 22, 3664. https://doi.org/10.3390/cells11223664

TY - JOUR

T1 - Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases

T2 - Prospective Therapeutic and Biomarker Potential

AU - Khan, Farheen Badrealam

AU - Uddin, Shahab

AU - Elderdery, Abozer Y.

AU - Goh, Khang Wen

AU - Ming, Long Chiau

AU - Ardianto, Chrismawan

AU - Palakot, Abdul Rasheed

AU - Anwar, Irfa

AU - Khan, Mohsina

AU - Owais, Mohammad

AU - Huang, Chih Yang

AU - Daddam, Jayasimha Rayalu

AU - Khan, Meraj Alam

AU - Shoaib, Shoaib

AU - Khursheed, Md

AU - Reshadat, Sara

AU - Khayat Kashani, Hamid Reza

AU - Mirza, Sameer

AU - Khaleel, Abbas A.

AU - Ayoub, Mohammed Akli

N1 - Funding Information: Zayed Center for Health Sciences, United Arab Emirates University (UAEU-ZCHS) (Grant number #31R235) and the UAEU postdoc grant (Grant number #31R241). Funding Information: We acknowledge the funding support by a center-based grant from Zayed Center for Health Sciences, United Arab Emirates University. Publisher Copyright: © 2022 by the authors.

PY - 2022/11

Y1 - 2022/11

N2 - Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

AB - Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

KW - cardiovascular disease

KW - circRNA

KW - exosomes

KW - lncRNA

KW - miRNA

KW - ncRNA

UR - https://www.scopus.com/pages/publications/85142417726

U2 - 10.3390/cells11223664

DO - 10.3390/cells11223664

M3 - Review article

C2 - 36429092

AN - SCOPUS:85142417726

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 22

M1 - 3664

ER -

Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Abstract

Keywords

UN SDGs

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