Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Farheen Badrealam Khan; Shahab Uddin; Abozer Y. Elderdery; Khang Wen Goh; Long Chiau Ming; Chrismawan Ardianto; Abdul Rasheed Palakot; Irfa Anwar; Mohsina Khan; Mohammad Owais; Chih Yang Huang; Jayasimha Rayalu Daddam; Meraj Alam Khan; Shoaib Shoaib; Md Khursheed; Sara Reshadat; Hamid Reza Khayat Kashani; Sameer Mirza; Abbas A. Khaleel; Mohammed Akli Ayoub

doi:10.3390/cells11223664

Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Farheen Badrealam Khan
, Shahab Uddin
, Abozer Y. Elderdery
, Khang Wen Goh
, Long Chiau Ming
, Chrismawan Ardianto
, Abdul Rasheed Palakot
, Irfa Anwar
, Mohsina Khan
, Mohammad Owais
, Chih Yang Huang
, Jayasimha Rayalu Daddam
, Meraj Alam Khan
, Shoaib Shoaib
, Md Khursheed
, Sara Reshadat
, Hamid Reza Khayat Kashani
, Sameer Mirza
, Abbas A. Khaleel
, Mohammed Akli Ayoub

Biological Sciences

United Arab Emirates University
Oral Health Institute Hamad Medical Corporation
Jouf University
INTI International University
Universiti Brunei Darussalam
Universitas Airlangga
Icahn School of Medicine at Mount Sinai
Aligarh Muslim University
Asia University
China Medical University
Buddhist Tzu Chi Medical Foundation
Tzu Chi University of Science and Technology
China Medical University Hospital
Volcani Center
Hospital for Sick Children University of Toronto
Jawaharlal Nehru Medical College
Mohammed Bin Rashid University of Medicine and Health Sciences
Semnan University of Medical Sciences and Health Services
Imam Hossein Hospital

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

Original language	British English
Article number	3664
Journal	Cells
Volume	11
Issue number	22
DOIs	https://doi.org/10.3390/cells11223664
State	Published - Nov 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cardiovascular disease
circRNA
exosomes
lncRNA
miRNA
ncRNA

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Khan, F. B., Uddin, S., Elderdery, A. Y., Goh, K. W., Ming, L. C., Ardianto, C., Palakot, A. R., Anwar, I., Khan, M., Owais, M., Huang, C. Y., Daddam, J. R., Khan, M. A., Shoaib, S., Khursheed, M., Reshadat, S., Khayat Kashani, H. R., Mirza, S., Khaleel, A. A., & Ayoub, M. A. (2022). Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential. Cells, 11(22), Article 3664. https://doi.org/10.3390/cells11223664

@article{75ae12639c1047a7ac659a521ad7327c,

title = "Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential",

abstract = "Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.",

keywords = "cardiovascular disease, circRNA, exosomes, lncRNA, miRNA, ncRNA",

author = "Khan, \{Farheen Badrealam\} and Shahab Uddin and Elderdery, \{Abozer Y.\} and Goh, \{Khang Wen\} and Ming, \{Long Chiau\} and Chrismawan Ardianto and Palakot, \{Abdul Rasheed\} and Irfa Anwar and Mohsina Khan and Mohammad Owais and Huang, \{Chih Yang\} and Daddam, \{Jayasimha Rayalu\} and Khan, \{Meraj Alam\} and Shoaib Shoaib and Md Khursheed and Sara Reshadat and \{Khayat Kashani\}, \{Hamid Reza\} and Sameer Mirza and Khaleel, \{Abbas A.\} and Ayoub, \{Mohammed Akli\}",

note = "Funding Information: Zayed Center for Health Sciences, United Arab Emirates University (UAEU-ZCHS) (Grant number \#31R235) and the UAEU postdoc grant (Grant number \#31R241). Funding Information: We acknowledge the funding support by a center-based grant from Zayed Center for Health Sciences, United Arab Emirates University. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = nov,

doi = "10.3390/cells11223664",

language = "British English",

volume = "11",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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Khan, FB, Uddin, S, Elderdery, AY, Goh, KW, Ming, LC, Ardianto, C, Palakot, AR, Anwar, I, Khan, M, Owais, M, Huang, CY, Daddam, JR, Khan, MA, Shoaib, S, Khursheed, M, Reshadat, S, Khayat Kashani, HR, Mirza, S, Khaleel, AA & Ayoub, MA 2022, 'Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential', Cells, vol. 11, no. 22, 3664. https://doi.org/10.3390/cells11223664

TY - JOUR

T1 - Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases

T2 - Prospective Therapeutic and Biomarker Potential

AU - Khan, Farheen Badrealam

AU - Uddin, Shahab

AU - Elderdery, Abozer Y.

AU - Goh, Khang Wen

AU - Ming, Long Chiau

AU - Ardianto, Chrismawan

AU - Palakot, Abdul Rasheed

AU - Anwar, Irfa

AU - Khan, Mohsina

AU - Owais, Mohammad

AU - Huang, Chih Yang

AU - Daddam, Jayasimha Rayalu

AU - Khan, Meraj Alam

AU - Shoaib, Shoaib

AU - Khursheed, Md

AU - Reshadat, Sara

AU - Khayat Kashani, Hamid Reza

AU - Mirza, Sameer

AU - Khaleel, Abbas A.

AU - Ayoub, Mohammed Akli

N1 - Funding Information: Zayed Center for Health Sciences, United Arab Emirates University (UAEU-ZCHS) (Grant number #31R235) and the UAEU postdoc grant (Grant number #31R241). Funding Information: We acknowledge the funding support by a center-based grant from Zayed Center for Health Sciences, United Arab Emirates University. Publisher Copyright: © 2022 by the authors.

PY - 2022/11

Y1 - 2022/11

N2 - Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

AB - Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

KW - cardiovascular disease

KW - circRNA

KW - exosomes

KW - lncRNA

KW - miRNA

KW - ncRNA

UR - https://www.scopus.com/pages/publications/85142417726

U2 - 10.3390/cells11223664

DO - 10.3390/cells11223664

M3 - Review article

C2 - 36429092

AN - SCOPUS:85142417726

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 22

M1 - 3664

ER -

Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Abstract

UN SDGs

Keywords

Access to Document

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