IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis

Rui Sheng Duan, Xing Mei Zhang, Eilhard Mix, Hernan Concha Quezada, Abdu Adem, Jie Zhu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

IL-18 deficient (IL-18-/-) mice were used to investigate the role of IL-18 in the pathogenesis of experimental autoimmune neuritis (EAN) which was induced by immunization of the mice with P0 protein peptide 180-199. The clinical course was not different between IL-18-/- and wild-type mice. The splenic mononuclear cell (MNC) proliferation was also similar in both animal groups. However, the percentages of IFN-γ, IL-10 and IL-12 positive cells were decreased among infiltrating MNC of cauda equine in IL-18-/- mice. This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.

Original languageBritish English
Pages (from-to)162-167
Number of pages6
JournalJournal of Neuroimmunology
Volume183
Issue number1-2
DOIs
StatePublished - Feb 2007

Keywords

  • EAN
  • IL-18
  • Th1 cytokines
  • Th2 cytokines

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