Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national

Wael Abdrabou; Ini Isabée Witzel; Agnieszka Paduch; Guan Tay; Habiba Alsafar

doi:10.1016/j.humimm.2016.05.010

Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national

Wael Abdrabou
, Ini Isabée Witzel
, Agnieszka Paduch
, Guan Tay
, Habiba Alsafar

Biomedical Engineering & Biotechnology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.

Original language	British English
Pages (from-to)	605-608
Number of pages	4
Journal	Human Immunology
Volume	77
Issue number	7
DOIs	https://doi.org/10.1016/j.humimm.2016.05.010
State	Published - 1 Jul 2016

Keywords

Arab genetics
HLA-A01:195
Novel HLA-A allele
Sequence based typing

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title = "Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national",

abstract = "A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine \#124 to valine.",

keywords = "Arab genetics, HLA-A01:195, Novel HLA-A allele, Sequence based typing",

author = "Wael Abdrabou and Witzel, \{Ini Isab{\'e}e\} and Agnieszka Paduch and Guan Tay and Habiba Alsafar",

note = "Funding Information: Funding for this project was provided by Khalifa University through the Khalifa Internal Research Fund Level 1 (KUIRF1). We would like to thank Biduth Radharaman and Ismahen Ammar for their technical assistance. We are also in debt to the volunteers who contribute to our studies. Publisher Copyright: {\textcopyright} 2016 American Society for Histocompatibility and Immunogenetics",

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AU - Witzel, Ini Isabée

AU - Paduch, Agnieszka

AU - Tay, Guan

AU - Alsafar, Habiba

N1 - Funding Information: Funding for this project was provided by Khalifa University through the Khalifa Internal Research Fund Level 1 (KUIRF1). We would like to thank Biduth Radharaman and Ismahen Ammar for their technical assistance. We are also in debt to the volunteers who contribute to our studies. Publisher Copyright: © 2016 American Society for Histocompatibility and Immunogenetics

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N2 - A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.

AB - A novel human leucocyte antigen (HLA)-A allele, HLA-A01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.

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KW - Novel HLA-A allele

KW - Sequence based typing

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JO - Human Immunology

JF - Human Immunology

IS - 7

ER -

Identification of a novel HLA-A allele, HLA-A01:195, in a UAE national

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Keywords

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