Hydrocyanines: A class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and in vivo

Kousik Kundu, Sarah F. Knight, Nick Willett, Sungmun Lee, W. Robert Taylor, Niren Murthy

Research output: Contribution to journalArticlepeer-review

295 Scopus citations

Abstract

Accurate and tunable: The title compounds can detect reactive oxygen species (ROS) in cell culture, tissue explants, and for the first time in vivo. The hydrocyanines are synthesized by reduction of the cyanine dyes with NaBH4. They can accurately detect nanomolar levels of ROS, have excellent stability against autoxidation, and have tunable emission wavelengths in the range 560-830 nm. (Figure Presented).

Original languageBritish English
Pages (from-to)299-303
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number2
DOIs
StatePublished - 2 Jan 2009

Keywords

  • Cyanines
  • Fluorescence
  • Hydrocyanines
  • Reactive oxygen species
  • Superoxide

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