HPLC analysis in drug level monitoring of K027

S. Nurulain; H. Kalász; P. Szegi; K. Kuca; A. Adem; M. Hasan; F. Hashemi; K. Tekes

doi:10.1556/AChrom.25.2013.4.8

HPLC analysis in drug level monitoring of K027

S. Nurulain, H. Kalász, P. Szegi, K. Kuca, A. Adem, M. Hasan, F. Hashemi, K. Tekes

College of Medicine and Health Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

Original language	British English
Pages (from-to)	703-710
Number of pages	8
Journal	Acta Chromatographica
Volume	25
Issue number	4
DOIs	https://doi.org/10.1556/AChrom.25.2013.4.8
State	Published - 1 Dec 2013

Keywords

blood-brain barrier
HPLC
K027
pharmacokinetics
quantitation
reversed-phase separation

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10.1556/AChrom.25.2013.4.8

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title = "HPLC analysis in drug level monitoring of K027",

abstract = "HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.",

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AU - Nurulain, S.

AU - Kalász, H.

AU - Szegi, P.

AU - Kuca, K.

AU - Adem, A.

AU - Hasan, M.

AU - Hashemi, F.

AU - Tekes, K.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

AB - HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

KW - blood-brain barrier

KW - HPLC

KW - K027

KW - pharmacokinetics

KW - quantitation

KW - reversed-phase separation

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SN - 1233-2356

VL - 25

SP - 703

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JO - Acta Chromatographica

JF - Acta Chromatographica

IS - 4

ER -

HPLC analysis in drug level monitoring of K027

Abstract

Keywords

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