HPLC analysis in drug level monitoring of K027

S. Nurulain, H. Kalász, P. Szegi, K. Kuca, A. Adem, M. Hasan, F. Hashemi, K. Tekes

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.

Original languageBritish English
Pages (from-to)703-710
Number of pages8
JournalActa Chromatographica
Issue number4
StatePublished - 1 Dec 2013


  • blood-brain barrier
  • HPLC
  • K027
  • pharmacokinetics
  • quantitation
  • reversed-phase separation


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