HPLC analysis and detection of L-deprenyl

V. Csomor; R. Laufer; Z. Pöstényi; H. Kalász; E. Adeghate; S. M. Nurulain; K. Tekes; A. Adem

doi:10.1556/AChrom.26.2014.4.7

HPLC analysis and detection of L-deprenyl

V. Csomor, R. Laufer, Z. Pöstényi, H. Kalász, E. Adeghate, S. M. Nurulain, K. Tekes, A. Adem

College of Medicine and Health Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

L-Deprenyl and its major metabolites were subjected to reversed-phase highperformance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected L-deprenyl, L-nordeprenyl, L-methamphetamine, and L-amphetamine. Amperometric detection was specific and sensitive to the parent compound (L-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.

Original language	British English
Pages (from-to)	649-656
Number of pages	8
Journal	Acta Chromatographica
Volume	26
Issue number	4
DOIs	https://doi.org/10.1556/AChrom.26.2014.4.7
State	Published - 1 Dec 2014

Keywords

Amperometric detection
HPLC
L-deprenyl
Metabolites
UV detection

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10.1556/AChrom.26.2014.4.7

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title = "HPLC analysis and detection of L-deprenyl",

abstract = "L-Deprenyl and its major metabolites were subjected to reversed-phase highperformance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected L-deprenyl, L-nordeprenyl, L-methamphetamine, and L-amphetamine. Amperometric detection was specific and sensitive to the parent compound (L-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.",

keywords = "Amperometric detection, HPLC, L-deprenyl, Metabolites, UV detection",

author = "V. Csomor and R. Laufer and Z. P{\"o}st{\'e}nyi and H. Kal{\'a}sz and E. Adeghate and Nurulain, {S. M.} and K. Tekes and A. Adem",

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T1 - HPLC analysis and detection of L-deprenyl

AU - Csomor, V.

AU - Laufer, R.

AU - Pöstényi, Z.

AU - Kalász, H.

AU - Adeghate, E.

AU - Nurulain, S. M.

AU - Tekes, K.

AU - Adem, A.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - L-Deprenyl and its major metabolites were subjected to reversed-phase highperformance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected L-deprenyl, L-nordeprenyl, L-methamphetamine, and L-amphetamine. Amperometric detection was specific and sensitive to the parent compound (L-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.

AB - L-Deprenyl and its major metabolites were subjected to reversed-phase highperformance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected L-deprenyl, L-nordeprenyl, L-methamphetamine, and L-amphetamine. Amperometric detection was specific and sensitive to the parent compound (L-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.

KW - Amperometric detection

KW - HPLC

KW - L-deprenyl

KW - Metabolites

KW - UV detection

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DO - 10.1556/AChrom.26.2014.4.7

M3 - Article

AN - SCOPUS:84928562924

SN - 1233-2356

VL - 26

SP - 649

EP - 656

JO - Acta Chromatographica

JF - Acta Chromatographica

IS - 4

ER -

HPLC analysis and detection of L-deprenyl

Abstract

Keywords

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