How nanoparticles encapsulating fluorophores allow a double detection of biomolecules by localized surface plasmon resonance and luminescence

G. Barbillon, A. C. Faure, N. El Kork, P. Moretti, S. Roux, O. Tillement, M. G. Ou, A. Descamps, P. Perriat, A. Vial, J. L. Bijeon, C. A. Marquette, B. Jacquier

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The paper shows how polysiloxane particles encapsulating fluorophores can be successfully used to detect biotin-streptavidin binding by two types of technique. After functionalization of the particles by streptavidin, the fixation of the biomolecule can indeed be detected by a shift of the localized surface plasmon resonance of the biotinylated gold dots used as substrate and by the luminescence of the fluorophores evidenced by scanning near-field optical microscopy. The development of particles allowing such a double detection opens a route for increasing the reliability of biological detection and for multi-labelling strategies crossing both detection principles.

Original languageBritish English
Article number035705
JournalNanotechnology
Volume19
Issue number3
DOIs
StatePublished - 23 Jan 2008

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