Historical prospective cohort study of the recurrence of pain after discontinuation of treatment with danazol or a gonadotropin-releasing hormone agonist

James D. Miller, Robert W. Shaw, Robert F.J. Casper, John A. Rock, Eric J. Thomas, W. Paul Dmowski, Eric Surrey, L. Russel Malinak, Kamran Moghissi

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Objective: To determine the duration of time to the recurrence of pain attributable to endometriosis after the discontinuation of treatment with danazol or a GnRH agonist (GnRH-a) in patients who have had a satisfactory response to the treatment. Design: Retrospective study. Setting: Nine academic medical centers in three countries. Patient(s): Three hundred twenty-seven women with diagnosed and staged endometriosis who were treated with at least 6 months of danazol or a GnRH-a and who experienced significant pain relief with therapy. Intervention(s): None. Main Outcome Measure(s): Duration of pain relief after completion of treatment as determined by a patient-initiated report of pain recurrence or increase in pain severity requiring intervention. Result(s): The median time to the recurrence of pain was 6.1 months for patients treated with danazol and 5.2 months for patients treated with a GnRH-a. Conclusion(s): Although there was a lack of uniformity in treatment effects across sites, the analyses have taken into account major covariant effects. The time to the recurrence of endometriosis-associated pain after danazol treatment was slightly longer than that after GnRH-a treatment.

Original languageBritish English
Pages (from-to)293-296
Number of pages4
JournalFertility and Sterility
Volume70
Issue number2
DOIs
StatePublished - Aug 1998

Keywords

  • Danazol
  • Efficacy
  • Endometriosis
  • GnRH agonist
  • Pain recurrence

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