Histogenesis of the retina in murine trisomy 19

Dietrich E. Lorke; Heinz Winking

doi:10.1016/0361-9230(86)90080-8

Histogenesis of the retina in murine trisomy 19

Dietrich E. Lorke, Heinz Winking

College of Medicine and Health Sciences

University of Lübeck

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Retinal development of trisomy 19 (Ts19) mice has been studied by microscopy from postnatal day 2 (PD 2) to PD 15. Gross malformations of the eye or alterations of the cellular arrangement are not detectable; retinal differentiation follows the regular pattern observed in chromosomally balanced control littermates. At all stages examined, the development of the retina in Ts 19 lags approximately 2 days behind littermate controls. The maturation of all cellular constituents examined is retarded to the same degree. Appearance of the outer plexiform layer, cessation of mitotic activity, penetration of blood vessels in the nerve fiber layer and in the outer plexiform layer, differentiation of the inner granular layer and receptor formation are each delayed about two days. On a cellular level, there is no indication for an asynchronous development in the retina of Ts19. In addition to the retarded maturation, the diameters of the eyes are reduced in Ts19 mice.

Original language	British English
Pages (from-to)	845-851
Number of pages	7
Journal	Brain Research Bulletin
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/0361-9230(86)90080-8
State	Published - Jun 1986

Keywords

Mouse
Postnatal development
Retina
Trisomy 19

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10.1016/0361-9230(86)90080-8

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title = "Histogenesis of the retina in murine trisomy 19",

abstract = "Retinal development of trisomy 19 (Ts19) mice has been studied by microscopy from postnatal day 2 (PD 2) to PD 15. Gross malformations of the eye or alterations of the cellular arrangement are not detectable; retinal differentiation follows the regular pattern observed in chromosomally balanced control littermates. At all stages examined, the development of the retina in Ts 19 lags approximately 2 days behind littermate controls. The maturation of all cellular constituents examined is retarded to the same degree. Appearance of the outer plexiform layer, cessation of mitotic activity, penetration of blood vessels in the nerve fiber layer and in the outer plexiform layer, differentiation of the inner granular layer and receptor formation are each delayed about two days. On a cellular level, there is no indication for an asynchronous development in the retina of Ts19. In addition to the retarded maturation, the diameters of the eyes are reduced in Ts19 mice.",

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T1 - Histogenesis of the retina in murine trisomy 19

AU - Lorke, Dietrich E.

AU - Winking, Heinz

PY - 1986/6

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N2 - Retinal development of trisomy 19 (Ts19) mice has been studied by microscopy from postnatal day 2 (PD 2) to PD 15. Gross malformations of the eye or alterations of the cellular arrangement are not detectable; retinal differentiation follows the regular pattern observed in chromosomally balanced control littermates. At all stages examined, the development of the retina in Ts 19 lags approximately 2 days behind littermate controls. The maturation of all cellular constituents examined is retarded to the same degree. Appearance of the outer plexiform layer, cessation of mitotic activity, penetration of blood vessels in the nerve fiber layer and in the outer plexiform layer, differentiation of the inner granular layer and receptor formation are each delayed about two days. On a cellular level, there is no indication for an asynchronous development in the retina of Ts19. In addition to the retarded maturation, the diameters of the eyes are reduced in Ts19 mice.

AB - Retinal development of trisomy 19 (Ts19) mice has been studied by microscopy from postnatal day 2 (PD 2) to PD 15. Gross malformations of the eye or alterations of the cellular arrangement are not detectable; retinal differentiation follows the regular pattern observed in chromosomally balanced control littermates. At all stages examined, the development of the retina in Ts 19 lags approximately 2 days behind littermate controls. The maturation of all cellular constituents examined is retarded to the same degree. Appearance of the outer plexiform layer, cessation of mitotic activity, penetration of blood vessels in the nerve fiber layer and in the outer plexiform layer, differentiation of the inner granular layer and receptor formation are each delayed about two days. On a cellular level, there is no indication for an asynchronous development in the retina of Ts19. In addition to the retarded maturation, the diameters of the eyes are reduced in Ts19 mice.

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KW - Trisomy 19

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Histogenesis of the retina in murine trisomy 19

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