Abstract
The synthesis of spiro compounds through a Michael-Michael-aldol reaction is reported. The reaction affords spiropyrazolone derivatives in good yields, in almost diastereo- and enantiopure form, and is catalyzed by diphenylprolinol derivatives. The reaction showed strong nonlinear effects. Remarkably, when a catalyst with 70 ee is used, the reaction still affords the final spiro compound in almost diastereo- and enantiopure form.
| Original language | British English |
|---|---|
| Pages (from-to) | 1318-1325 |
| Number of pages | 8 |
| Journal | European Journal of Organic Chemistry |
| Issue number | 7 |
| DOIs | |
| State | Published - Mar 2011 |
Keywords
- Diastereoselectivity
- Enantioselectivity
- Michael addition
- Organocatalysis
- Spiro compounds
Fingerprint
Dive into the research topics of 'Highly stereoselective synthesis of spiropyrazolones'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver