Highly regio- and diastereoselective oxazol-5-one addition to nitrostyrenes

Andrea Nekane Balaguer, Xavier Companyó, Teresa Calvet, Mercé Font-Bardía, Albert Moyano, Ramon Rios

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


A convenient and novel oxazol-5-one addition to nitrostyrenes is reported. The reaction is catalyzed by tertiary amines and yields the corresponding adducts with total regio- and diastereoselectivity. The addition exclusively takes place at the C-2 position of oxazol-5-ones, furnishing diastereopure N,O-aminals.

Original languageBritish English
Pages (from-to)199-203
Number of pages5
JournalEuropean Journal of Organic Chemistry
Issue number2
StatePublished - Jan 2009


  • Diastereoselective catalysis
  • Heterocycles
  • Michael addition
  • N,O-aminals
  • Nitrostyrenes
  • Organocatalysis


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