TY - JOUR
T1 - Highly Hydrophilic Oleylamine-Modified Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications
AU - Karouta, Niki
AU - Simos, Yannis V.
AU - Basina, Georgia
AU - Spyrou, Konstantinos
AU - Subrati, Mohammed
AU - Chatzikonstantinou, Alexandra V.
AU - Hammami, Mohamed Amen
AU - Tzitzios, Vasileios
AU - Alhassan, Saeed M.
AU - Al Wahedi, Yasser
AU - Douvalis, Alexios P.
AU - Hadjipanayis, George C.
AU - Tsamis, Konstantinos
AU - Dounousi, Evangelia
AU - Markopoulos, Georgios S.
AU - Bellou, Sofia
AU - Georgakilas, Vasilios
AU - Peschos, Dimitrios
AU - Sideratou, Zili
AU - Stamatis, Haralambos
AU - Gournis, Dimitrios P.
AU - Giannelis, Emmanuel P.
N1 - Funding Information:
N.K. gratefully acknowledges the IKY Foundation for financial support: This research is co-financed by Greece and the European Union (European Social Fund, ESF) through the Operational Program ≪Human Resources Development, Education, and Lifelong Learning≫ in the context of the project “Strengthening Human Resources Research Potential via Doctorate Research” (MIS-5000432), implemented by the State Scholarships Foundation (IKY).
Publisher Copyright:
© 2023 American Chemical Society.
PY - 2022
Y1 - 2022
N2 - Superparamagnetic iron oxide nanoparticles (SPIONs) are becoming important vehicles for biomedical applications. This study demonstrates a new strategy based on a “haircut” reaction, aiming at the design of highly hydrophilic and functional nanoparticles. The as-synthesized SPIONs have a diameter of ∼4 nm and reveal super-organophilic behavior due to their surface modification by oleylamine molecules present on their surface (o-SPIONs). The “trimming”, which is applied on the oleylamine molecule double bond, produces shorter chains terminated by carboxyl groups, with the resulting nanoparticles exhibiting high hydrophilicity, dispersibility in water, and functionality (h-SPIONs). The biological behavior of h-SPIONs is studied against three different cell lines and reveals a selective cytotoxic effect against cancer cells. This novel method of engineering the surface properties of nanoparticles can lead to the development of a new generation of functional nanomaterials. In addition, h-SPIONs can evolve into a new and expanding family of magnetic nanomaterials in future biomedical systems.
AB - Superparamagnetic iron oxide nanoparticles (SPIONs) are becoming important vehicles for biomedical applications. This study demonstrates a new strategy based on a “haircut” reaction, aiming at the design of highly hydrophilic and functional nanoparticles. The as-synthesized SPIONs have a diameter of ∼4 nm and reveal super-organophilic behavior due to their surface modification by oleylamine molecules present on their surface (o-SPIONs). The “trimming”, which is applied on the oleylamine molecule double bond, produces shorter chains terminated by carboxyl groups, with the resulting nanoparticles exhibiting high hydrophilicity, dispersibility in water, and functionality (h-SPIONs). The biological behavior of h-SPIONs is studied against three different cell lines and reveals a selective cytotoxic effect against cancer cells. This novel method of engineering the surface properties of nanoparticles can lead to the development of a new generation of functional nanomaterials. In addition, h-SPIONs can evolve into a new and expanding family of magnetic nanomaterials in future biomedical systems.
KW - biomedical applications
KW - cytotoxicity
KW - dispersibility
KW - hydrophilic functionalization
KW - magnetic nanoparticles
UR - https://www.scopus.com/pages/publications/85148447903
U2 - 10.1021/acsanm.2c04006
DO - 10.1021/acsanm.2c04006
M3 - Article
AN - SCOPUS:85148447903
SN - 2574-0970
JO - ACS Applied Nano Materials
JF - ACS Applied Nano Materials
ER -
