Highly Enantioselective Synthesis of Alkylpyridine Derivatives through a Michael/Michael/Aldol Cascade Reaction

Marta Meazza, Michael Potter, Mateusz B. Pitak, Simon J. Coles, Andrea Mazzanti, Ramon Rios

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A method for the synthesis of pyridine derivatives based on a triple cascade reaction catalyzed by chiral secondary amines was developed. The resulting cyclohexenes (three C–C bonds were formed) were obtained in good yields with good diastereoselectivities and excellent enantioselectivities.

Original languageBritish English
Pages (from-to)719-725
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number3
DOIs
StatePublished - 18 Jan 2017

Keywords

  • Domino reactions
  • Enantioselectivity
  • Michael addition
  • Nitrogen heterocycles
  • Organocatalysis

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