Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction

Ramon Rios; Henrik Sundén; Ismail Ibrahem; Gui Ling Zhao; Lars Eriksson; Armando Córdova

doi:10.1016/j.tetlet.2006.09.135

Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction

Ramon Rios
, Henrik Sundén
, Ismail Ibrahem
, Gui Ling Zhao
, Lars Eriksson
, Armando Córdova

Chemistry

Arrhenius Laboratory

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

A highly enantioselective catalytic asymmetric synthesis of 2H-1-benzothiopyrans is presented. The organocatalytic asymmetric domino reactions between 2-mercaptobenzaldehyde and α,β-unsaturated aldehydes proceed with excellent chemo- and enantioselectivities to give the corresponding pharmaceutically valuable benzothiopyrans in high yields with 91-98% ee.

Original language	British English
Pages (from-to)	8547-8551
Number of pages	5
Journal	Tetrahedron Letters
Volume	47
Issue number	48
DOIs	https://doi.org/10.1016/j.tetlet.2006.09.135
State	Published - 27 Nov 2006

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title = "Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction",

abstract = "A highly enantioselective catalytic asymmetric synthesis of 2H-1-benzothiopyrans is presented. The organocatalytic asymmetric domino reactions between 2-mercaptobenzaldehyde and α,β-unsaturated aldehydes proceed with excellent chemo- and enantioselectivities to give the corresponding pharmaceutically valuable benzothiopyrans in high yields with 91-98\% ee.",

author = "Ramon Rios and Henrik Sund{\'e}n and Ismail Ibrahem and Zhao, \{Gui Ling\} and Lars Eriksson and Armando C{\'o}rdova",

note = "Funding Information: We gratefully acknowledge the Swedish National Research Council and Carl-Trygger Foundation for financial support.",

year = "2006",

month = nov,

day = "27",

doi = "10.1016/j.tetlet.2006.09.135",

language = "British English",

volume = "47",

pages = "8547--8551",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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number = "48",

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TY - JOUR

T1 - Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction

AU - Rios, Ramon

AU - Sundén, Henrik

AU - Ibrahem, Ismail

AU - Zhao, Gui Ling

AU - Eriksson, Lars

AU - Córdova, Armando

N1 - Funding Information: We gratefully acknowledge the Swedish National Research Council and Carl-Trygger Foundation for financial support.

PY - 2006/11/27

Y1 - 2006/11/27

N2 - A highly enantioselective catalytic asymmetric synthesis of 2H-1-benzothiopyrans is presented. The organocatalytic asymmetric domino reactions between 2-mercaptobenzaldehyde and α,β-unsaturated aldehydes proceed with excellent chemo- and enantioselectivities to give the corresponding pharmaceutically valuable benzothiopyrans in high yields with 91-98% ee.

AB - A highly enantioselective catalytic asymmetric synthesis of 2H-1-benzothiopyrans is presented. The organocatalytic asymmetric domino reactions between 2-mercaptobenzaldehyde and α,β-unsaturated aldehydes proceed with excellent chemo- and enantioselectivities to give the corresponding pharmaceutically valuable benzothiopyrans in high yields with 91-98% ee.

UR - https://www.scopus.com/pages/publications/33750307526

U2 - 10.1016/j.tetlet.2006.09.135

DO - 10.1016/j.tetlet.2006.09.135

M3 - Article

AN - SCOPUS:33750307526

SN - 0040-4039

VL - 47

SP - 8547

EP - 8551

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 48

ER -

Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction

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