Highly enantioselective synthesis of 2H-1-benzothiopyrans by a catalytic domino reaction

Ramon Rios, Henrik Sundén, Ismail Ibrahem, Gui Ling Zhao, Lars Eriksson, Armando Córdova

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124 Scopus citations

Abstract

A highly enantioselective catalytic asymmetric synthesis of 2H-1-benzothiopyrans is presented. The organocatalytic asymmetric domino reactions between 2-mercaptobenzaldehyde and α,β-unsaturated aldehydes proceed with excellent chemo- and enantioselectivities to give the corresponding pharmaceutically valuable benzothiopyrans in high yields with 91-98% ee.

Original languageBritish English
Pages (from-to)8547-8551
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number48
DOIs
StatePublished - 27 Nov 2006

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