@article{3177dc9fd1544c129c999be254b6787f,
title = "Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine",
abstract = "A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps.",
author = "Guillem Valero and Jiri Schimer and Ivana Cisarova and Jan Vesely and Albert Moyano and Ramon Rios",
note = "Funding Information: We would like to thank J. Terr{\'o}n, M. V{\'a}zquez, and M. Spiropulu for useful comments and experimental information. This work has been partially supported by the DGICYT (Spain) under Projects No. FPA2000-0956 and No. BFM2002-01003. ",
year = "2009",
month = apr,
day = "29",
doi = "10.1016/j.tetlet.2009.02.049",
language = "British English",
volume = "50",
pages = "1943--1946",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd",
number = "17",
}