Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine

Guillem Valero, Jiri Schimer, Ivana Cisarova, Jan Vesely, Albert Moyano, Ramon Rios

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps.

Original languageBritish English
Pages (from-to)1943-1946
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number17
DOIs
StatePublished - 29 Apr 2009

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