Highly enantioselective fluoromalonate addition to α,β-unsaturated aldehydes

Xavier Companyó; Monika Hejnová; Martin Kamlar; Jan Vesely; Albert Moyano; Ramon Rios

doi:10.1016/j.tetlet.2009.06.092

Highly enantioselective fluoromalonate addition to α,β-unsaturated aldehydes

Xavier Companyó
, Monika Hejnová
, Martin Kamlar
, Jan Vesely
, Albert Moyano
, Ramon Rios

Chemistry

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

A highly enantioselective organocatalytic fluoromalonate addition to α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding 1,4-adducts with high yields and enantioselectivities.

Original language	British English
Pages (from-to)	5021-5024
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	35
DOIs	https://doi.org/10.1016/j.tetlet.2009.06.092
State	Published - 2 Sep 2009

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title = "Highly enantioselective fluoromalonate addition to α,β-unsaturated aldehydes",

abstract = "A highly enantioselective organocatalytic fluoromalonate addition to α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding 1,4-adducts with high yields and enantioselectivities.",

author = "Xavier Company{\'o} and Monika Hejnov{\'a} and Martin Kamlar and Jan Vesely and Albert Moyano and Ramon Rios",

note = "Funding Information: We thank the Spanish Ministry of Science and Innovation for financial support (Project AYA2006-15648-C02-01) and the Ministry of Education of the Czech Republic for financial support, Grant No. MSM0021620857.",

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T1 - Highly enantioselective fluoromalonate addition to α,β-unsaturated aldehydes

AU - Companyó, Xavier

AU - Hejnová, Monika

AU - Kamlar, Martin

AU - Vesely, Jan

AU - Moyano, Albert

AU - Rios, Ramon

N1 - Funding Information: We thank the Spanish Ministry of Science and Innovation for financial support (Project AYA2006-15648-C02-01) and the Ministry of Education of the Czech Republic for financial support, Grant No. MSM0021620857.

PY - 2009/9/2

Y1 - 2009/9/2

N2 - A highly enantioselective organocatalytic fluoromalonate addition to α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding 1,4-adducts with high yields and enantioselectivities.

AB - A highly enantioselective organocatalytic fluoromalonate addition to α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding 1,4-adducts with high yields and enantioselectivities.

UR - https://www.scopus.com/pages/publications/67650252003

U2 - 10.1016/j.tetlet.2009.06.092

DO - 10.1016/j.tetlet.2009.06.092

M3 - Article

AN - SCOPUS:67650252003

SN - 0040-4039

VL - 50

SP - 5021

EP - 5024

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35

ER -

Highly enantioselective fluoromalonate addition to α,β-unsaturated aldehydes

Abstract

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