Abstract
An efficient synthesis of spiropyrazolones based on organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo- and enantioselectivities.
| Original language | British English |
|---|---|
| Pages (from-to) | 6519-6523 |
| Number of pages | 5 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 9 |
| Issue number | 19 |
| DOIs | |
| State | Published - 7 Oct 2011 |
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