Highly enantioselective cascade synthesis of spiropyrazolones

Alex Zea, Andrea Nekane R. Alba, Andrea Mazzanti, Albert Moyano, Ramon Rios

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

An efficient synthesis of spiropyrazolones based on organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo- and enantioselectivities.

Original languageBritish English
Pages (from-to)6519-6523
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number19
DOIs
StatePublished - 7 Oct 2011

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