Highly diastereoselective synthesis of spiropyrazolones

Victor Ceban; Temitope O. Olomola; Marta Meazza; Ramon Rios

doi:10.3390/molecules20058574

Highly diastereoselective synthesis of spiropyrazolones

Victor Ceban, Temitope O. Olomola, Marta Meazza, Ramon Rios

Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

Original language	British English
Pages (from-to)	8574-8582
Number of pages	9
Journal	Molecules
Volume	20
Issue number	5
DOIs	https://doi.org/10.3390/molecules20058574
State	Published - 2015

Keywords

Cascade Reaction
Diastereoselective
Spiropyrazolones

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10.3390/molecules20058574

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title = "Highly diastereoselective synthesis of spiropyrazolones",

abstract = "We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.",

keywords = "Cascade Reaction, Diastereoselective, Spiropyrazolones",

author = "Victor Ceban and Olomola, {Temitope O.} and Marta Meazza and Ramon Rios",

note = "Publisher Copyright: {\textcopyright} 2015 by the authors.",

year = "2015",

doi = "10.3390/molecules20058574",

language = "British English",

volume = "20",

pages = "8574--8582",

journal = "Molecules",

issn = "1420-3049",

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T1 - Highly diastereoselective synthesis of spiropyrazolones

AU - Ceban, Victor

AU - Olomola, Temitope O.

AU - Meazza, Marta

AU - Rios, Ramon

PY - 2015

Y1 - 2015

N2 - We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

AB - We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

KW - Cascade Reaction

KW - Diastereoselective

KW - Spiropyrazolones

UR - http://www.scopus.com/inward/record.url?scp=84938360628&partnerID=8YFLogxK

U2 - 10.3390/molecules20058574

DO - 10.3390/molecules20058574

M3 - Article

C2 - 25985358

AN - SCOPUS:84938360628

SN - 1420-3049

VL - 20

SP - 8574

EP - 8582

JO - Molecules

JF - Molecules

IS - 5

ER -

Highly diastereoselective synthesis of spiropyrazolones

Abstract

Keywords

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