@article{31351bdd692044198cdd359f5c68c702,
title = "Highly Diastereo- and Enantioselective Synthesis of α-Spiro-δ-lactams by an Organocascade Reaction",
abstract = "An asymmetric synthesis of α-spiro-δ-lactams by an organocascade reaction of easily accessible starting materials has been accomplished. The catalytic sequence begins with enantioselective Michael addition of a β-ketoamide to an α,β-unsaturated aldehyde, catalyzed by a secondary amine catalyst, and is followed by hemiaminal annulation. Optically enantiopure compounds with three stereogenic centres are obtained in good yields and excellent selectivities (up to >20:1 dr and up to >99 \% ee).",
keywords = "Asymmetric synthesis, Enantioselectivity, Michael addition, Organocatalysis, Spirolactams",
author = "Kaiheng Zhang and Marta Meazza and Vojt{\v e}ch Do{\v c}ekal and Light, \{Mark E.\} and Jan Vesel{\'y} and Ramon Rios",
note = "Funding Information: K. Z., M. M. and R. R. are grateful for Engineering and Physical Sciences Research Council (EPSRC) Core Capability Funding (EP/K039466/1). V. D. and J. V. gratefully acknowledge financial support from the Charles University Grant Agency (393615). We thank Diamond Light Source for the allocation of beamtime MT8521 on beamline I19. Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",
year = "2017",
month = apr,
day = "3",
doi = "10.1002/ejoc.201700193",
language = "British English",
volume = "2017",
pages = "1749--1756",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
publisher = "Wiley-VCH Verlag",
number = "13",
}