Abstract
Highly enantioselective organocatalytic domino thia-Michael/aldol reactions between 2-mercaptoacetophenone and α,β-unsaturated aldehydes are presented. The reactions proceed with excellent chemo-, diastereo- and enantioselectivity to give the corresponding benzothiopyran derivatives in high yields with up to > 15:1 dr and 96 to > 99% ee.
Original language | British English |
---|---|
Pages (from-to) | 237-242 |
Number of pages | 6 |
Journal | Advanced Synthesis and Catalysis |
Volume | 350 |
Issue number | 2 |
DOIs | |
State | Published - Jan 2008 |
Keywords
- α,β-Unsaturated Aldehydes
- Asymmetric catalysis
- Benzothiopyrans
- Domino reactions
- Thia-Michael reaction