@article{2b8a0a3aeb3b4c69be949dc2d4c18a3b,
title = "Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents",
abstract = "A cascade reaction of thioamides with 6β-bromoandrostenedione in hexafluoroisopropanol formed substituted thiazolo-androstenones. This is a simple and mild protocol to synthesize novel molecules by using readily available reagents and substrates. Feasibility of the reaction has been rationalized by density functional theory calculations. Moreover, these compounds are potent growth inhibitors of colon, central nervous system, melanoma, ovarian, and renal cancer cell lines with 50\% growth inhibition values as low as 1.04 μM.",
author = "Christina Okolo and Ali, \{Mohamad Akbar\} and Matthew Newman and Chambers, \{Steven A.\} and Jedidiah Whitt and Alsharif, \{Zakeyah A.\} and Day, \{Victor W.\} and Alam, \{Mohammad A.\}",
note = "Funding Information: We are thankful to the INBRE for a pilot grant (grant \#224658) and ABI mini-grant 200138. This publication was made possible by the Research Technology Core of the Arkansas INBRE Program, supported by a grant from the National Institute of General Medical Sciences, (NIGMS), P20 GM103429-16 from the National Institutes of Health to record the Mass Spectrometry data. We are thankful to Dr Victor, Director/Senior Scientist X-ray Crystallography Laboratory University of Kansas, (NSF-MRI grant CHE-0923449) for recording crystal structure of compounds. M.A.A. thanks National Research Foundation of South Korea for the financial support. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = dec,
day = "21",
doi = "10.1021/acsomega.8b02840",
language = "British English",
volume = "3",
pages = "17991--18001",
journal = "ACS Omega",
issn = "2470-1343",
publisher = "American Chemical Society",
number = "12",
}
