@article{22838fe0525a40d7851acb778a4d462d,
title = "Hexafluoroisopropanol mediated benign synthesis of 2: H -pyrido[1,2- a] pyrimidin-2-ones by using a domino protocol",
abstract = "A domino strategy has been used for the synthesis of 2H-pyrido[1,2-a]pyrimidin-2-ones. Four sequential reactions: aza-Michael addition, water elimination, intramolecular acyl substitution, and [1,3]-H shift were observed in this domino protocol. Hexafluoroisopropanol is used as a promotor and recyclable solvent in this cascade process. The availability of inexpensive 2-aminopyridines and a wide variety of Michael acceptors such as commercially available acrylates and unactivated Baylis-Hillman adducts makes this methodology a huge reservoir of novel fused N-heterocycles as bioactive and potential therapeutic agents. The reaction mechanism has been proposed and rationalized by density functional theory calculations. Products are obtained in up to 95% yield.",
author = "Zakeyah Alsharif and Ali, {Mohamad Akbar} and Hessa Alkhattabi and Derika Jones and Evan Delancey and Ravikumar, {P. C.} and Alam, {Mohammad A.}",
note = "Funding Information: This work was supported by the College of Science and Mathematics, Arkansas State University, Jonesboro. Arkansas Statewide MS facility, Grant Number P30 GM103450, from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) is acknowledged for performing mass spectrometry. This publication was made possible by the Arkansas INBRE program, supported by grant funding from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) (P20 GM103429). MAA thanks the provost office for help completing this work by giving an FRAC award and ABI-Astate for (Grant number: Start-up 200126) start-up funding. Hessa and Zakeyah are thankful to the Saudi Arabian Cultural Mission (SACM) for sponsoring their scholarship. M. A. Ali thanks Sejong University, Seoul and the KISTI supercomputer for the computational resources. Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.",
year = "2017",
doi = "10.1039/c7nj03376a",
language = "British English",
volume = "41",
pages = "14862--14870",
journal = "New Journal of Chemistry",
issn = "1144-0546",
publisher = "Royal Society of Chemistry",
number = "24",
}
