TY - GEN
T1 - Heart rate variability and QT dispersion in a cohort of diabetes patients
AU - Jelinek, Herbert F.
AU - Khandoker, Ahsan
AU - Palaniswami, Marimuthu
AU - McDonald, Simon
PY - 2010
Y1 - 2010
N2 - Heart rate is dependent on a cycle of depolarization and repolarization of the atria and ventricles that is regulated by intrinsic and extrinsic factors. Inhomogeneity in ventricular repolarization, measured as QT interval dispersion (QTd) is likely to lead to arrhythmia. The role of the autonomic nervous system in the development of this inhomogeneity is still uncertain. Autonomic regulation can be measured using the toneentropy algorithm, which indicates inter-beat interval variation.When a sliding cut-off for QTd was used only the control group had a significant association between QTd and both tone and entropy. This finding suggests that for certain levels of ventricular inhomogeneity, autonomic control becomes more dissociated from intrabeta variation measured by QTd. This may be an early sign of potentially fatal arrhythmia.
AB - Heart rate is dependent on a cycle of depolarization and repolarization of the atria and ventricles that is regulated by intrinsic and extrinsic factors. Inhomogeneity in ventricular repolarization, measured as QT interval dispersion (QTd) is likely to lead to arrhythmia. The role of the autonomic nervous system in the development of this inhomogeneity is still uncertain. Autonomic regulation can be measured using the toneentropy algorithm, which indicates inter-beat interval variation.When a sliding cut-off for QTd was used only the control group had a significant association between QTd and both tone and entropy. This finding suggests that for certain levels of ventricular inhomogeneity, autonomic control becomes more dissociated from intrabeta variation measured by QTd. This may be an early sign of potentially fatal arrhythmia.
UR - http://www.scopus.com/inward/record.url?scp=79953818016&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:79953818016
SN - 9781424473182
T3 - Computing in Cardiology
SP - 613
EP - 616
BT - Computing in Cardiology 2010, CinC 2010
T2 - Computing in Cardiology 2010, CinC 2010
Y2 - 26 September 2010 through 29 September 2010
ER -