Healthcare applications of pH-sensitive hydrogel-based devices: A review

Asail Hendi, Muhammad Umair Hassan, Mohamed Elsherif, Bader Alqattan, Seongjun Park, Ali Kemal Yetisen, Haider Butt

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


pH-sensitive hydrogels have been developed greatly over the past few years. This has been possible due to the synthesis of new hydrogel systems with increased sensitivity – a sensitivity of up to 10−5 pH units has already been established. Recently, pH-sensitive hydrogels have shown to be very useful in biomedical applications, such as targeted cancer treatment and treatment of skin lesions. Prolonged drug release has been made available through the use of such hydrogels. The synthesis of pH-sensitive hydrogels is also quick and cost-effective. This review presents a background on the properties of pH-sensitive hydrogels and discusses some of the hydrogels with different sensitivity ranges and their possible applications. A range of synthesis processes have also been briefly introduced along with the fabrication of different structures such as microcantilevers and contact lenses.

Original languageBritish English
Pages (from-to)3887-3901
Number of pages15
JournalInternational Journal of Nanomedicine
StatePublished - 2020


  • Biocompatible
  • Biomedical applications
  • Hydrogels
  • pH-sensitive
  • Sensors


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