H-Gemcitabine: A new gemcitabine prodrug for treating cancer

Madhuri Dasari; Abhinav P. Acharya; Dongin Kim; Seungjun Lee; Sungmun Lee; Jeanne Rhea; Ross Molinaro; Niren Murthy

doi:10.1021/bc300095m

H-Gemcitabine: A new gemcitabine prodrug for treating cancer

Madhuri Dasari
, Abhinav P. Acharya
, Dongin Kim
, Seungjun Lee
, Sungmun Lee
, Jeanne Rhea
, Ross Molinaro
, Niren Murthy

Biomedical Engineering & Biotechnology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

In this report, we present a new strategy for targeting chemotherapeutics to tumors, based on targeting extracellular DNA. A gemcitabine prodrug was synthesized, termed H-gemcitabine, which is composed of Hoechst conjugated to gemcitabine. H-gemcitabine has low toxicity because it is membrane-impermeable; however, it still has high tumor efficacy because of its ability to target gemcitabine to E-DNA in tumors. We demonstrate here that H-gemcitabine has a wider therapeutic window than free gemcitabine.

Original language	British English
Pages (from-to)	4-8
Number of pages	5
Journal	Bioconjugate Chemistry
Volume	24
Issue number	1
DOIs	https://doi.org/10.1021/bc300095m
State	Published - 16 Jan 2013

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10.1021/bc300095m

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title = "H-Gemcitabine: A new gemcitabine prodrug for treating cancer",

abstract = "In this report, we present a new strategy for targeting chemotherapeutics to tumors, based on targeting extracellular DNA. A gemcitabine prodrug was synthesized, termed H-gemcitabine, which is composed of Hoechst conjugated to gemcitabine. H-gemcitabine has low toxicity because it is membrane-impermeable; however, it still has high tumor efficacy because of its ability to target gemcitabine to E-DNA in tumors. We demonstrate here that H-gemcitabine has a wider therapeutic window than free gemcitabine.",

author = "Madhuri Dasari and Acharya, \{Abhinav P.\} and Dongin Kim and Seungjun Lee and Sungmun Lee and Jeanne Rhea and Ross Molinaro and Niren Murthy",

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T1 - H-Gemcitabine

T2 - A new gemcitabine prodrug for treating cancer

AU - Dasari, Madhuri

AU - Acharya, Abhinav P.

AU - Kim, Dongin

AU - Lee, Seungjun

AU - Lee, Sungmun

AU - Rhea, Jeanne

AU - Molinaro, Ross

AU - Murthy, Niren

PY - 2013/1/16

Y1 - 2013/1/16

N2 - In this report, we present a new strategy for targeting chemotherapeutics to tumors, based on targeting extracellular DNA. A gemcitabine prodrug was synthesized, termed H-gemcitabine, which is composed of Hoechst conjugated to gemcitabine. H-gemcitabine has low toxicity because it is membrane-impermeable; however, it still has high tumor efficacy because of its ability to target gemcitabine to E-DNA in tumors. We demonstrate here that H-gemcitabine has a wider therapeutic window than free gemcitabine.

AB - In this report, we present a new strategy for targeting chemotherapeutics to tumors, based on targeting extracellular DNA. A gemcitabine prodrug was synthesized, termed H-gemcitabine, which is composed of Hoechst conjugated to gemcitabine. H-gemcitabine has low toxicity because it is membrane-impermeable; however, it still has high tumor efficacy because of its ability to target gemcitabine to E-DNA in tumors. We demonstrate here that H-gemcitabine has a wider therapeutic window than free gemcitabine.

UR - https://www.scopus.com/pages/publications/84872540658

U2 - 10.1021/bc300095m

DO - 10.1021/bc300095m

M3 - Article

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AN - SCOPUS:84872540658

SN - 1043-1802

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EP - 8

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 1

ER -

H-Gemcitabine: A new gemcitabine prodrug for treating cancer

Abstract

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