Genome-wide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering

Girish Srinivas, Steffen Möller, Jun Wang, Sven Künzel, Detlef Zillikens, John F. Baines, Saleh M. Ibrahim

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Susceptibility to chronic inflammatory diseases is determined by immunogenetic and environmental risk factors. Resident microbial communities often differ between healthy and diseased states, but whether these differences are of primary aetiological importance or secondary to the altered inflammatory environment remains largely unknown. Here we provide evidence for host gene-microbiota interactions contributing to disease risk in a mouse model of epidermolysis bullosa acquisita, an autoantibody-induced inflammatory skin disease. Using an advanced intercross, we identify genetic loci contributing to skin microbiota variability, susceptibility to skin blistering and their overlap. Furthermore, by treating bacterial species abundances as covariates with disease we reveal a novel disease locus. The majority of the identified covariate taxa are characterized by reduced abundance being associated with increased disease risk, providing evidence of a primary role in protection from disease. Further characterization of these putative probiotic species or species assemblages offers promising potential for preventative and therapeutic treatment development.

Original languageBritish English
Article number2462
JournalNature Communications
Volume4
DOIs
StatePublished - 2013

Fingerprint

Dive into the research topics of 'Genome-wide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering'. Together they form a unique fingerprint.

Cite this