TY - JOUR
T1 - Genome-wide association analysis of HDL-C in a Lebanese cohort
AU - Deek, Rebecca
AU - Nasser, Jason
AU - Ghanem, Anthony
AU - Mardelli, Marc
AU - Khazen, Georges
AU - Salloum, Angelique K.
AU - Abchee, Antoine
AU - Ghassibe-Sabbagh, Michella
AU - Zalloua, Pierre
N1 - Publisher Copyright:
© 2019 Deek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/6
Y1 - 2019/6
N2 - Low serum levels of high-density lipoprotein cholesterol (HDL-C) have been shown to be a risk factor for coronary artery disease independent of low-density lipoprotein cholesterol (LDL-C) in different populations. In this study, we investigated genetic variants through genome-wide association studies to determine their association with HDL-C levels in a sample of 2,700 patients. We identified several SNPs associated with HDL-C levels in the Lebanese population using unadjusted and adjusted by biological factors models. We replicated the association of rs3764261 within CETP with HDL-C levels in the study population, and found other previously unidentified SNPs to be significant at the suggestive level, in both previously identified and unidentified genes. This paper reports the first genome-wide analysis of HDL-C in the Lebanese, Middle Eastern, population and supports the importance of genome-wide association studies across different and minor ethnicities to understand better the etiology of complex human diseases.
AB - Low serum levels of high-density lipoprotein cholesterol (HDL-C) have been shown to be a risk factor for coronary artery disease independent of low-density lipoprotein cholesterol (LDL-C) in different populations. In this study, we investigated genetic variants through genome-wide association studies to determine their association with HDL-C levels in a sample of 2,700 patients. We identified several SNPs associated with HDL-C levels in the Lebanese population using unadjusted and adjusted by biological factors models. We replicated the association of rs3764261 within CETP with HDL-C levels in the study population, and found other previously unidentified SNPs to be significant at the suggestive level, in both previously identified and unidentified genes. This paper reports the first genome-wide analysis of HDL-C in the Lebanese, Middle Eastern, population and supports the importance of genome-wide association studies across different and minor ethnicities to understand better the etiology of complex human diseases.
UR - http://www.scopus.com/inward/record.url?scp=85067379527&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0218443
DO - 10.1371/journal.pone.0218443
M3 - Article
C2 - 31211820
AN - SCOPUS:85067379527
SN - 1932-6203
VL - 14
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0218443
ER -
