Genetic Control of Spontaneous Arthritis in a Four-Way Advanced Intercross Line

Laura Mellado Ranea, Andreia de Castro Marques, Steffen Möller, Yask Gupta, Saleh M. Ibrahim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Identifying the genetic basis of complex diseases, such as rheumatoid arthritis, remains a challenge that requires experimental models to reduce the genetic and environmental variability. Numerous loci for arthritis have been identified in induced animal models; however, few spontaneous models have been genetically studied. Therefore, we generated a four-way advanced intercross line (AIL) from four inbred strains, including BXD2/TyJ which spontaneously develops autoimmune arthritis. A genome-wide scan for spontaneous arthritis was performed in a cohort of 366 mice of the fourth generation (G4) of this cross. Five loci contributing to clinical phenotypes were identified in chromosomes 3, 7, 13, 18, and X. Three of the loci found in this study, confirm previously identified loci; whereas two of them are novel loci. Interesting candidate genes for the loci are highlighted. This study provides a genetic overview of spontaneous arthritis in mice and aids to solve the genetic etiology of rheumatoid arthritis and to gain a better understanding of the disease.

Original languageBritish English
Article numbere75611
JournalPLoS ONE
Volume8
Issue number10
DOIs
StatePublished - 11 Oct 2013

Fingerprint

Dive into the research topics of 'Genetic Control of Spontaneous Arthritis in a Four-Way Advanced Intercross Line'. Together they form a unique fingerprint.

Cite this