Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk

Michella Ghassibe-Sabbagh; Daniel E. Platt; Sonia Youhanna; Antoine B. Abchee; Krista Stewart; Danielle A. Badro; Marc Haber; Angelique K. Salloum; Bouchra Douaihy; Hamid el Bayeh; Raed Othman; Nabil Shasha; Samer Kibbani; Elie Chammas; Aline Milane; Rita Nemr; Yoichiro Kamatani; Jörg Hager; Jean Baptiste Cazier; Dominique Gauguier; Pierre A. Zalloua

doi:10.1016/j.atherosclerosis.2012.02.035

Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk

Michella Ghassibe-Sabbagh, Daniel E. Platt, Sonia Youhanna, Antoine B. Abchee, Krista Stewart, Danielle A. Badro, Marc Haber, Angelique K. Salloum, Bouchra Douaihy, Hamid el Bayeh, Raed Othman, Nabil Shasha, Samer Kibbani, Elie Chammas, Aline Milane, Rita Nemr, Yoichiro Kamatani, Jörg Hager, Jean Baptiste Cazier, Dominique GauguierPierre A. Zalloua

College of Medicine and Health Sciences

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction.

Original language	British English
Pages (from-to)	180-186
Number of pages	7
Journal	Atherosclerosis
Volume	222
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.02.035
State	Published - May 2012

Keywords

Coronary artery disease (CAD)
Diuretics
Homocysteine
Hyperhomocysteinemia
Hypertension
Lebanese population

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2012.02.035

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Ghassibe-Sabbagh, M., Platt, D. E., Youhanna, S., Abchee, A. B., Stewart, K., Badro, D. A., Haber, M., Salloum, A. K., Douaihy, B., el Bayeh, H., Othman, R., Shasha, N., Kibbani, S., Chammas, E., Milane, A., Nemr, R., Kamatani, Y., Hager, J., Cazier, J. B., ... Zalloua, P. A. (2012). Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk. Atherosclerosis, 222(1), 180-186. https://doi.org/10.1016/j.atherosclerosis.2012.02.035

@article{9d48494e68354624a0c98113c6500052,

title = "Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk",

abstract = "Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction.",

keywords = "Coronary artery disease (CAD), Diuretics, Homocysteine, Hyperhomocysteinemia, Hypertension, Lebanese population",

author = "Michella Ghassibe-Sabbagh and Platt, {Daniel E.} and Sonia Youhanna and Abchee, {Antoine B.} and Krista Stewart and Badro, {Danielle A.} and Marc Haber and Salloum, {Angelique K.} and Bouchra Douaihy and {el Bayeh}, Hamid and Raed Othman and Nabil Shasha and Samer Kibbani and Elie Chammas and Aline Milane and Rita Nemr and Yoichiro Kamatani and J{\"o}rg Hager and Cazier, {Jean Baptiste} and Dominique Gauguier and Zalloua, {Pierre A.}",

note = "Funding Information: This work was supported by the Wellcome Trust core award [grant number 075491/Z/04 ]; the European Commission [FGENTCARD, grant number LSHG-CT-2006-037683 ]; the Wellcome Trust senior fellowship in basic biomedical science [grant number 057733 to D.G.]. ",

year = "2012",

month = may,

doi = "10.1016/j.atherosclerosis.2012.02.035",

language = "British English",

volume = "222",

pages = "180--186",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Ghassibe-Sabbagh, M, Platt, DE, Youhanna, S, Abchee, AB, Stewart, K, Badro, DA, Haber, M, Salloum, AK, Douaihy, B, el Bayeh, H, Othman, R, Shasha, N, Kibbani, S, Chammas, E, Milane, A, Nemr, R, Kamatani, Y, Hager, J, Cazier, JB, Gauguier, D & Zalloua, PA 2012, 'Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk', Atherosclerosis, vol. 222, no. 1, pp. 180-186. https://doi.org/10.1016/j.atherosclerosis.2012.02.035

TY - JOUR

T1 - Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk

AU - Ghassibe-Sabbagh, Michella

AU - Platt, Daniel E.

AU - Youhanna, Sonia

AU - Abchee, Antoine B.

AU - Stewart, Krista

AU - Badro, Danielle A.

AU - Haber, Marc

AU - Salloum, Angelique K.

AU - Douaihy, Bouchra

AU - el Bayeh, Hamid

AU - Othman, Raed

AU - Shasha, Nabil

AU - Kibbani, Samer

AU - Chammas, Elie

AU - Milane, Aline

AU - Nemr, Rita

AU - Kamatani, Yoichiro

AU - Hager, Jörg

AU - Cazier, Jean Baptiste

AU - Gauguier, Dominique

AU - Zalloua, Pierre A.

N1 - Funding Information: This work was supported by the Wellcome Trust core award [grant number 075491/Z/04 ]; the European Commission [FGENTCARD, grant number LSHG-CT-2006-037683 ]; the Wellcome Trust senior fellowship in basic biomedical science [grant number 057733 to D.G.].

PY - 2012/5

Y1 - 2012/5

N2 - Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction.

AB - Background: Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims: The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods: A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results: Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions: Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics' intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction.

KW - Coronary artery disease (CAD)

KW - Diuretics

KW - Homocysteine

KW - Hyperhomocysteinemia

KW - Hypertension

KW - Lebanese population

UR - http://www.scopus.com/inward/record.url?scp=84859877872&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2012.02.035

DO - 10.1016/j.atherosclerosis.2012.02.035

M3 - Article

C2 - 22425167

AN - SCOPUS:84859877872

SN - 0021-9150

VL - 222

SP - 180

EP - 186

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk

Abstract

Keywords

UN SDGs

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