Gene-expression profiling of experimental autoimmune encephalomyelitis

Eilhard Mix, Jens Pahnke, Saleh M. Ibrahim

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Experimental autoimmune encephalomyelitis (EAE) is a mouse model that serves as an experimental tool for studying the etiology, pathogenesis, as well as new therapeutic approaches of multiple sclerosis (MS). EAE is a polygenic chronic inflammatory demyelinating disease of the nervous system that involves the interaction between genetic and environmental factors. Previous studies have identified multiple quantitative trait loci (QTL) controlling different aspects of disease pathogenesis. However, progress in identifying new susceptibility genes outside the MHC locus has been slow. With the advent of new global methods for genetic analysis such as large-scale sequencing, gene expression profiling combined with classic linkage analysis and congenic and physical mapping progress is considerably accelerating. Here we review our preliminary work on the use of gene expression mapping to identify new putative genetic pathways contributing to the pathogenesis of EAE.

Original languageBritish English
Pages (from-to)1157-1163
Number of pages7
JournalNeurochemical Research
Issue number10
StatePublished - 1 Oct 2002


  • EAE
  • Multiple sclerosis
  • Oligonucleotide-microarrays
  • QTL


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